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Neuroinflammation is responsible for pain in endometriosis - targeting the JAK-STAT pathway and mast cell activation.

Chronic pain is a defining feature of endometriosis and contributes significantly to the diminished quality of life observed in affected individuals. Despite advances in understanding disease pathology, current therapeutic strategies …

Published: Aug. 29, 2025, midnight
Acupuncture monotherapy for endometriosis-related pain: A systematic review and meta-analysis.

This study evaluated the efficacy of acupuncture as a monotherapy for managing endometriosis-related pain (ERP) compared to non-acupuncture interventions.

Published: Aug. 28, 2025, midnight
A Multifunctional Molecular Probe for Multimodal Imaging-Guided Potent Photothermal/Photodynamic Therapy of Endometriosis.

Multifunctional small-molecule theranostic agents hold significant clinical potential for non-invasive endometriosis (EMS) management. Current EMS treatment faces challenges due to imprecise lesion localization and therapy-associated side effects. Herein, an integrated …

Published: Aug. 28, 2025, midnight
Feasibility, acceptability, and exploratory outcomes of a virtual cognitive behavioural therapy-based group intervention for persistent fatigue in endometriosis: The Managing Fatigue in Endometriosis (MEND) programme.

This study developed and assessed the feasibility, acceptability, and exploratory outcomes of a six-session cognitive behavioural therapy (CBT)-based intervention for endometriosis-related persistent fatigue, called Managing Fatigue in Endometriosis (MEND).

Published: Aug. 27, 2025, 12:01 a.m.
Emerging Mechanisms of NK Cell Dysfunction in Endometriosis: The Role of Autophagy, Metabolism, Cytokines, Exosomes, and Trogocytosis.

Endometriosis (EMS) is a persistent, inflammatory condition that relies on estrogen and is distinguished by the proliferation of endometrial tissue outside the confines of the uterus. The impact on the …

Published: Aug. 27, 2025, 12:01 a.m.
Nanotechnology strategies for endometrium health: Are we on the right track?

The endometrium is a vital mucosal tissue which undergoes cyclical regeneration, differentiation, and remodeling upon hormonal, cellular, and molecular signaling networks. Dysregulation of these processes can trigger a range of …

Published: Aug. 27, 2025, midnight
Metastatic Carcinomas at the Episiotomy Site: A Systematic Literature Review.

Background/Objectives: Rarely, primary (PriCs) or metastatic (metECs) carcinomas occur in the episiotomy site. Methods: A systematic literature review of metECs was carried out. We reviewed the PRISMA guidelines and the …

Published: Aug. 27, 2025, midnight
Spectrum of Histopathologic Findings in Transgender Men Undergoing Gender-Affirming Gynecologic Surgery Following Preoperative Androgen Therapy: A Tertiary Care Center Study.

IntroductionTransgender men are assigned female sex at birth, but identify with a masculine gender identity, prompting them to undergo gender-affirming surgery, usually following androgen therapy, which induces changes in histology …

Published: Aug. 26, 2025, midnight
Safety of current strategies to manage moderate to severe pain in patients with endometriosis.

Medical therapy is crucial in the long-term management of endometriosis, and its clinical efficacy must be balanced with a favorable safety profile.

Published: Aug. 25, 2025, midnight
Incidental Primary Ovarian Squamous Cell Carcinoma Arising in Endometriosis Presenting As Adenomyosis-Related Abnormal Uterine Bleeding.

Adenomyosis often coexists with endometriosis, which primarily involves the ovary and can lead to endometriosis‑associated ovarian cancers, most commonly endometrioid and clear‑cell carcinomas. Ovarian squamous cell carcinoma (OSCC) arising in …

Published: Aug. 22, 2025, midnight
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