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Myelofibrosis Trials: Diverging Narratives on Enrollment, Endpoint Clarity, and Safety Data - AInvest

Myelofibrosis Trials: Diverging Narratives on Enrollment, Endpoint Clarity, and Safety Data AInvest

Published: Aug. 11, 2025, 3:12 p.m.
C57BL/6J mice best recapitulate fibrosis and inflammatory pathophysiology in syngeneic mouse model of endometriosis.

Endometriosis (ENDO), a chronic inflammatory disease affecting approximately 190 million women globally, is characterized by fibrosis, a feature often challenging to replicate in murine models. To identify an optimal syngeneic …

Published: Aug. 8, 2025, midnight
Insights into the Molecular Mechanisms and Signaling Pathways of Epithelial to Mesenchymal Transition (EMT) in the Pathophysiology of Endometriosis.

Endometriosis is a disease characterized by the presence of endometrial glands and stroma outside of the uterine corpus, often clinically presenting with pain and/or infertility. Ectopic lesions exhibit features characteristic …

Published: Aug. 1, 2025, midnight
Microplastic exposure induces epithelial barrier alterations and increases collagen deposition in a 3D human endometrial model in vitro.

To investigate the effects of microplastics (MPs) on the human endometrium in vitro.

Published: Aug. 1, 2025, midnight
Activated eosinophil plays a role in promoting fibrosis in endometriotic lesion - Nature

Activated eosinophil plays a role in promoting fibrosis in endometriotic lesion Nature

Published: July 31, 2025, 9:03 p.m.
Activated eosinophil plays a role in promoting fibrosis in endometriotic lesion.

The fibrosis mechanism in endometriosis is not elucidated. We investigated the role of eosinophil in fibrosis of endometriosis. The endometriotic stromal cells (ESCs) and endometrial epithelial cells (EECs) were subjected …

Published: July 31, 2025, midnight
The Role of MRI in Diagnosis and Pre-Surgical Mapping of Endometriosis.

Endometriosis is a chronic multisystem disease caused by the presence of endometrium-like tissue outside the endometrial canal, inciting inflammation and fibrosis. Transvaginal ultrasound (TVUS) and MRI have replaced diagnostic laparoscopy …

Published: July 28, 2025, midnight
Menopause as a Critical Turning Point in Lipedema: The Estrogen Receptor Imbalance, Intracrine Estrogen, and Adipose Tissue Dysfunction Model.

Lipedema is a chronic, estrogen-sensitive adipose tissue disorder characterized by disproportionate subcutaneous fat accumulation, fibrosis, inflammation, and resistance to fat mobilization. Despite its high prevalence, lipedema remains poorly understood and …

Published: July 23, 2025, midnight
CCN5 negatively regulates TGF-β-induced endometriosis associated fibrosis through Wnt/β-catenin signaling via Smad3-dependent mechanism - Journal of Translational Medicine

CCN5 negatively regulates TGF-β-induced endometriosis associated fibrosis through Wnt/β-catenin signaling via Smad3-dependent mechanism Journal of Translational Medicine

Published: July 10, 2025, 7:44 a.m.
XBP1 promoted EMT and fibrosis in endometrial epithelial cells. (a)... - researchgate.net

XBP1 promoted EMT and fibrosis in endometrial epithelial cells. (a)... researchgate.net

Published: July 9, 2025, 7:31 p.m.
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