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The Nexus of Iron, Senescence, and Fibrosis in Endometriosis: A Narrative Review.

Endometriosis is a prevalent chronic inflammatory condition impacting 5-10% of reproductive-age women, commonly resulting in debilitating pelvic pain and infertility. Despite extensive research efforts, the precise underlying pathophysiology remains largely …

Published: Oct. 27, 2025, midnight
Molecular mechanisms and Biological Functions of Autophagy in Endometrial Diseases.

Autophagy is a highly conserved cellular process crucial for maintaining cellular homeostasis by degrading damaged organelles and misfolded proteins. Emerging evidence highlights its pivotal role in endometrial diseases, including endometriosis, …

Published: Oct. 27, 2025, midnight
Targeting Steroid Receptor Coactivators for the Treatment of Benign Female Reproductive Disorders.

Steroid receptor coactivators (SRCs) are master regulators of nuclear receptor signaling and play essential roles in female reproductive physiology. By integrating steroid hormone signaling with growth factors and metabolic pathways, …

Published: Oct. 23, 2025, midnight
Macrophages in endometriosis: key roles and emerging therapeutic opportunities-a narrative review.

Endometriosis is a chronic gynecological disorder affecting approximately 10% of women of reproductive age. It commonly presents with pelvic pain, dysmenorrhea, and infertility, imposing substantial physical, psychological, and social burdens. …

Published: Oct. 21, 2025, midnight
IL-6 Inhibits Invasion in a Murine Model of Endometriosis.

Endometriosis is a gynecological inflammatory disorder characterized by the presence of endometrial tissue outside of the uterus. It affects 10-15% of reproductive aged women, causing pelvic pain and infertility. Existing …

Published: Oct. 21, 2025, midnight
Addressing Meta-Inflammation in the Comprehensive Management of Chronic Pain.

Chronic pain is a widespread condition affecting millions globally, placing significant strain on healthcare systems, as evidenced by the current opioid crisis. Despite advances in pain management, conventional treatments often …

Published: Oct. 18, 2025, midnight
ROBO3 Drives Endometriosis Progression via Dual Wnt/β-Catenin Activation and M2 Macrophage Polarization.

Endometriosis, a prevalent gynecological disorder marked by ectopic growth of endometrial-like tissue, demonstrates malignant tumor-like properties including aggressive adhesion and invasiveness. Emerging evidence implicates roundabout guidance receptor 3 (ROBO3) in …

Published: Oct. 15, 2025, midnight
The Role of Antioxidant Minerals in the Pathophysiology and Treatment of Endometriosis-Systematic Review.

Endometriosis (EM) is a chronic gynecological disease of women of reproductive age. Due to the lack of a known cause, treatment is limited to reducing symptoms associated with pelvic pain …

Published: Oct. 15, 2025, midnight
NLRP3 Inflammasome in Gynecologic Inflammatory Diseases: Mechanisms, Pathophysiology, and Therapeutic Strategies.

The NOD-like receptor family containing pyridine domain 3 (NLRP3) inflammasome serves as a pivotal mediator of innate immune responses and a central driver of inflammatory processes. Upon detection of pathogenic …

Published: Oct. 10, 2025, midnight
Whispers of the Lungs: Unraveling the Mystery of Catamenial Pneumothorax.

Catamenial pneumothorax (CP) is an uncommon condition marked by recurrent spontaneous pneumothorax in women, typically occurring within the first 72 hours of menstruation. It is also the most prevalent manifestation …

Published: Oct. 9, 2025, midnight
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