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Efficacy and Safety of Elagolix Versus Dienogest for Treatment of Moderate-to-Severe Endometriosis Pain: A Phase III, Multicentric, Double-Blind, Active-Controlled, Non-Inferiority Study.

To compare the efficacy, safety and tolerability of elagolix with dienogest in women with moderate-to-severe endometriosis-associated pain.

Published: May 11, 2026, midnight
[Catamenial Pneumothorax During Endometriosis Treatment].

Here, we report a case of catamenial pneumothorax that occurred during endometriosis treatment. A 46-year-old woman presented with a history of right pneumothorax. At 43 years of age, the patient …

Published: May 9, 2026, midnight
Somatic mutations in endometrial epithelium: biological insights and emerging in vitro models.

The human endometrium is a complex, dynamic and poorly understood tissue involving monthly cyclical regeneration likely from adult stem/progenitor cells. This regeneration is associated with reproductive pathologies, such as endometriosis …

Published: May 9, 2026, midnight
Mortality risk associated with endometriosis: a systematic review and meta-analysis.

Endometriosis is a chronic, estrogen-dependent gynecological disorder affecting approximately 10% of women worldwide that can cause pelvic pain, lead to infertility, and impair quality of life. Whether the condition elevates …

Published: May 8, 2026, midnight
Neutrophil-to-lymphocyte ratio (nlr) as a predictor of endometriosis occurrence and prognosis: Evidence from a single-center study in Indonesia.

Endometriosis is a chronic inflammatory condition characterized by the presence of endometrial tissue outside the uterus, leading to pelvic pain and infertility. It affects approximately 10% of women of reproductive …

Published: May 8, 2026, midnight
Dose-Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload.

Iron overload induces cellular stress and is implicated in diverse pathological conditions. Nevertheless, the epigenetic mechanisms governing mammalian cellular responses to iron overload remain poorly characterized. Using multi-omics profiling in …

Published: May 7, 2026, midnight
The main active monomer of Dan'e-fukang soft extract, liquiritin, inhibits the inflammation and invasion of ectopic endometrial stromal cells through down-regulation of CCL2.

The study explored the mechanism of Dan'e-fukang soft extract in treating endometriosis (EMs) through network pharmacology. The main active ingredients of Dan'e-fukang soft extract were analyzed based on the traditional …

Published: May 7, 2026, midnight
A novel mouse model of endometriosis: Simulating the recurrent hemorrhagic microenvironment of clinical lesions.

Current models of endometriosis (EMs) still have limitations in replicating the key pathological features of human EMs, particularly the cyclic bleeding associated with ectopic lesions. To address this gap, this …

Published: May 6, 2026, midnight
Curcumin attenuates uterine pain in mice through suppression of neuroinflammation in the DRG and spinal cord.

Uterine pain associated with labor, dysmenorrhea, or endometriosis is often driven by inflammation, which enhances nociceptive signaling and contributes to hyperalgesia. Although nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids are commonly …

Published: May 6, 2026, midnight
Differential Antioxidant Capacities of Human Endometriotic and Endometrial Cell Models Under H2O2 Exposure.

Endometriosis is associated with oxidative stress and debilitating symptoms, yet its pathophysiology remains incompletely understood, and current treatments are still limited. In this study, oxidative stress responses were compared in …

Published: May 5, 2026, midnight
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