Latest Articles

Multimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care.

Chronic overlapping pain conditions (COPCs) refer to a set of chronic pain disorders that frequently co-occur and may involve partially overlapping mechanisms. The U.S. National Institutes of Health currently recognizes …

Pain and functional outcomes after surgical versus hormonal treatment in rectovaginal endometriosis: a retrospective cohort study.

To compare changes in pain-related symptoms, bowel and bladder function, rectal bleeding, quality of life, and treatment satisfaction in women with rectovaginal endometriosis treated either surgically or with hormonal treatment …

Path beyond the blind end-unravel the imaging spectrum of appendiceal pathologies.

The appendix is involved in a diverse spectrum of inflammatory, infectious, benign, and malignant conditions that extend far beyond acute appendicitis. Although acute appendicitis remains the most common appendiceal emergency, …

Beyond Pain Relief: Quality of Life and Functional Outcomes Following Minimally Invasive Excision of Deep Endometriosis.

Deep infiltrating endometriosis (DIE), particularly when involving the bowel, significantly impairs health-related quality of life (HRQoL) and gastrointestinal function. This study aimed to evaluate the short- and mid-term impact of …

Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry.

Anxiety is heritable and exists on a continuum, with symptoms ranging from adaptive threat response to clinical disorder. Here we performed a genome-wide association meta-analysis of generalized anxiety symptom severity …

Gut-reproduction axis: genome-wide pleiotropic and prospective evidence linking inflammatory bowel disease with gynecological disorders.

We aimed to explore shared genetic architectures and potential causal associations between inflammatory bowel disease (IBD) and gynecological diseases, including ovarian cysts (OC), pelvic inflammatory disease (PID), and endometriosis (EMs), …

Management of bowel dysfunction after pelvic surgery for endometriosis.

Bowel dysfunction is a common and debilitating condition affecting patients with endometriosis. Despite the extent of surgery, symptoms may persist or arise, often overlapping with low anterior resection syndrome (LARS) …

To cut or not to cut? Intraoperative ultrasound to identify deep bowel endometriosis.

Pain Relief, Gastrointestinal Function, and Recurrence After Conservative versus Radical (Segmental Resection) Surgery for Bowel Endometriosis: A Prospective Cohort Study.

Surgery represents a primary treatment option in selected cases of bowel endometriosis (BE), particularly in patients with significant symptoms or those unresponsive to medical therapy, and effectively improves patients' quality …

Citizen science reveals comorbidities in endometriosis with no shift in vaginal microbiome composition.

Endometriosis is a chronic inflammatory condition affecting 2-10% of reproductive-aged women, most commonly presenting with pelvic pain and subfertility. While its impact on reproductive health is increasingly recognized, the vaginal …