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The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency.

The LYSET gene encodes the LYSET transmembrane protein, which regulates lysosome biogenesis by activating the mannose-6-phosphate (M6P) pathway. This is an autosomal recessive, ultrarare, and severe progressive skeletal dysplasia with …

Published: March 20, 2026, midnight
Dysfunctional white adipose tissue in the progression of endometriosis: The role of the renin-angiotensin system.

Obesity is a multifactorial chronic disease with pandemic-level prevalence, characterized by excessive or abnormal fat accumulation, dysregulation of body homeostasis, and chronic low-grade inflammation. This complex comorbidity shares some etiological …

Published: March 20, 2026, midnight
Endometriosis of the spleen - multidisciplinary surgical solution in a patient with a complex picture of deep infiltrating pelvic endometriosis.

In general, most common localizations of endometriosis are the pelvic organs, until recently, the spleen was mentioned as the only abdominal organ resistant to the development of endometriosis. Our case …

Published: March 18, 2026, midnight
Epigenetic biomarkers of progestin-resistance in endometriosis.

Published: March 18, 2026, midnight
Repeatedly occurring retrograde menstruation intensifies central sensitization driven by neuroinflammation in endometriosis models.

This study investigated how chronic pelvic pain (CPP) develops using rhesus macaques with naturally occurring endometriosis and a multiple-lesion induction mouse model (MIM), as repeated retrograde menstruation is considered an …

Published: March 17, 2026, midnight
Misregulated alternative splicing in endometriosis: a role for aberrant mRNA variants in endometriotic cell growth.

Endometriosis is a chronic gynecological disorder marked by the growth of endometrial-like tissue outside the uterus, often leading to pelvic pain, inflammation, and infertility. Despite its global prevalence, diagnosis remains …

Published: March 15, 2026, midnight
Physical Activity, Metabolic Dysfunction, and the Kynurenine Pathway in Endometriosis and Polycystic Ovary Syndrome: A Literature Review.

Endometriosis and PCOS are both leading causes of female infertility, each affecting approximately 10% of reproductive-aged women worldwide. Both conditions markedly impair quality of life by affecting physical health, emotional …

Published: March 15, 2026, midnight
Pelvic pain and a missing kidney: Unveiling OHVIRA syndrome with a tubo-ovarian abscess.

Herlyn-Werner-Wunderlich syndrome (OHVIRA syndrome) is a rare congenital anomaly involving the Müllerian and renal systems, classically presenting as uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis. Due to its rarity …

Published: March 14, 2026, midnight
[Expression of Concern] Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis.

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the histopathological images shown in Fig. 3 on p. 90, …

Published: March 13, 2026, midnight
Unraveling the genetic links between stature and disease in East Asians: A multi-biobank genetic correlation and risk prediction study.

Both genetic and environmental factors affect human stature, including overall height and familial short stature (FSS), and it is associated with various health outcomes. However, the study of genetic connections …

Published: March 13, 2026, midnight
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