Fucoxanthin regulates macrophage pyroptosis through the PI3K/AKT/mTOR signalling pathway.
Pyroptosis has been reported to occur in several diseases, such as atherosclerosis, nonalcoholic steatohepatitis, and endometriosis. Although fucoxanthin has several biological properties (particularly anti-inflammatory properties), the mechanism through which fucoxanthin …
AI-Enhanced MRI Radiomics for Discriminating Active and Fibrotic Lesions to Support Therapeutic Decision-Making in Deep Endometriosis.
This study investigates whether quantitative analysis of preoperative Magnetic Resonance Imaging (MRI) scans can differentiate deep infiltrating endometriosis (DIE) lesion types (active or fibrotic) and associate them with reported pain …
Applications of Exosomes in Female Medicine: A Systematic Review of Molecular Biology, Diagnostic and Therapeutic Perspectives.
Exosomes are nanoscale extracellular vesicles that mediate intercellular communication by transporting microRNAs, proteins, and lipids. Generated through Endosomal Sorting Complex Required for Transport (ESCRT)-dependent mechanisms or ESCRT-independent pathways, exosomes are …
SLC25A1-Mediated Cholesterol Accumulation Promotes Endometriosis Progression by Enhancing Endometrial Stromal Cell Proliferation, Invasion, and M2 Macrophage Polarization.
Endometriosis is an estrogen-dependent chronic inflammatory disorder. Cholesterol (CHO) has been reported to be closely associated with estrogen synthesis and inflammatory responses. Nevertheless, the mechanisms underlying the effects of cholesterol …