SLC25A1-Mediated Cholesterol Accumulation Promotes Endometriosis Progression by Enhancing Endometrial Stromal Cell Proliferation, Invasion, and M2 Macrophage Polarization.
Endometriosis is an estrogen-dependent chronic inflammatory disorder. Cholesterol (CHO) has been reported to be closely associated with estrogen synthesis and inflammatory responses. Nevertheless, the mechanisms underlying the effects of cholesterol …
Kisspeptins inhibit ectopic endometrial cell invasion and angiogenesis by suppressing PI3K/AKT signaling pathway via CREB5 in endometriosis.
Endometriosis (EMs) is a common gynecological disorder. According to the most widely recognized theory of retrograde menstruation, endometrial cells require completion of three key steps during ectopic implantation: adhesion, invasion, …
Is exercise duration more important than intensity in endometriosis?
Exercise may be a useful adjunct treatment strategy to manage symptom severity and improve quality of life of women with endometriosis. This cross-sectional observational study aimed to investigate the associations …
Expanding the spectrum of AFF2 undifferentiated sarcoma associated to endometriosis: a novel ZDHHC9::AFF2 fusion sarcoma with high-grade features and poor prognosis.
The AFF2 gene encodes a protein involved in transcriptional regulation and chromatin remodeling. While primarily associated with Fragile X syndrome, AFF2 fusions have recently been identified in certain malignancies, mostly …
The Role of Catastrophizing in Enhancing Pain Interference and Depressive Symptoms in Endometriosis: A Longitudinal Examination.
Endometriosis is a prevalent condition characterised by chronic pelvic pain, significantly impacting women's quality of life and well-being. Pain catastrophizing is a cognitive tendency of exaggerated worrying, a sense of …
PRMT3-mediated FOXO1 arginine methylation exacerbates oxidative stress-induced decidualization defects in the eutopic endometrium of endometriosis.
Endometriosis is a hormone dependent disease that often accompanies infertility. At present, the incidence rate of endometriosis is on the rise, but its pathogenesis and the mechanism leading to fertility …
In Situ Characterization and Deep Profiling of Engineered Multispecific Nanoparticle Metabolite Coronas for Precise Serum Diagnostics.
Upon exposure to biofluids, engineered nanoparticles (NPs) spontaneously form reproducible biomolecular coronas via selective diverse biomolecule adsorption. The corona characterization of metabolites poses greater analytical challenges than proteins due to …