Latest Articles

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From gut to gamete: how the microbiome influences fertility and preconception health.

Global fertility rates continue to decline despite advancements in assisted reproductive technologies, highlighting a significant gap in our understanding of the mechanisms underlying preconception physiology. In this commentary, we review …

Published: Sept. 26, 2025, midnight
Clinical Application of Cell Therapy in the Treatment of Female Reproductive Diseases: A Systematic Review.

Reproductive disorders affect millions of women worldwide, playing a crucial role in determining female fertility health and quality of life. Conventional methods such as surgery, hormone therapy, and assisted reproductive …

Published: Sept. 23, 2025, midnight
Clinical practice guidelines for the care of people experiencing chronic primary pain: protocol for a systematic review with interpretation against an established chronic pain care priority framework.

Most clinical practice guidelines (CPGs) for assessing and managing people's chronic pain focus on specific pain conditions, body sites or life course stages. This creates complexity for clinicians making care …

Published: Sept. 18, 2025, midnight
Evaluation of the need for the integration of a nurse specialist (EndoNurse) into the interdisciplinary care of patients with endometriosis: Cross-sectional study.

Like other chronic diseases, endometriosis also requires long-term, individualized and multidisciplinary care. The integration of specialized nursing care has already been proven in other chronic diseases, but it is unclear …

Published: Sept. 18, 2025, midnight
Endometriosis and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis.

Background/Objectives: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and endometriosis are debilitating conditions that share overlapping features of chronic inflammation and immune dysregulation, yet their epidemiological relationship remains poorly characterized. The objective …

Published: Sept. 15, 2025, midnight
M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits.

Endometriosis is a common gynecologic condition that causes chronic, life-altering symptoms including pain and infertility. There is an urgent need for new non-hormonal targeted therapeutics to treat endometriosis, but until …

Published: Sept. 12, 2025, midnight
Efficacy of Elagolix and Relugolix for the Treatment of Pelvic Pain in Patients With Endometriosis: A Systematic Review.

Endometriosis is a chronic gynecological condition commonly associated with pelvic pain, dysmenorrhea, dyspareunia, and infertility. Owing to the limitations and adverse effects of traditional hormonal therapies, this study aimed to …

Published: Sept. 12, 2025, midnight
The Role of Endometriosis in Intestinal Inflammation: A Combined Mendelian Randomization and Cellular Study.

This study aims to assess whether endometriosis causally increases the risk of IBD through Mendelian randomisation (MR) analysis and to elucidate potential mechanisms using in vitro experiments. A two-sample Mendelian …

Published: Sept. 10, 2025, midnight
Elevating and empowering reproductive futures: Pediatric and adolescent gynecology's specialized care across the globe.

Pediatric and adolescent gynecology (PAG) is an expanding subspecialty of obstetrics and gynecology that addresses the reproductive health needs of girls and young women worldwide. In regions with limited subspecialist …

Published: Sept. 5, 2025, midnight
Multi-ancestry genome-wide association study of endometriosis and its clinical manifestations in ~1.4 million women: translating gene discovery into pathogenic mechanisms and therapeutic targets.

We conducted a multi-ancestry genome-wide association study of endometriosis and adenomyosis in almost 1.4 million women, including 105,869 cases, aiming to expand endometriosis loci discovery across ancestries, dissect symptom-specific effects, …

Published: Sept. 5, 2025, midnight
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