The concept of ferroptosis debuted as a newly defined programmed cell death in 2012. Among programmed cell death mechanisms, ferroptosis stands out as being fundamentally dependent on iron. At the …
Ovarian endometriosis is an estrogen-dependent inflammatory disorder in which endometrial stromal cells are key cellular contributors to hormone-immune crosstalk and lesion persistence. Here, we isolated paired eutopic (NESC) and ectopic …
Introduction Endometriosis is a common cause of infertility and affects reproductive outcomes through multiple mechanisms, including pelvic adhesions, altered pelvic anatomy, and inflammatory changes. The Endometriosis Fertility Index (EFI) was …
Endometrial dysfunction represents a central pathological factor underlying recurrent implantation failure and infertility. This review provides a comprehensive synthesis of the physiological basis of endometrial function, the pathological factors compromising …
Endometriosis is a prevalent benign condition among women of reproductive age. While the overall rate of endometriosis-associated malignancy is low, the risk of malignant transformation increases significantly in postmenopausal patients, …
The female reproductive tract (FRT), particularly the vagina, has traditionally been regarded as a sterile environment. However, it is now recognized that the vagina is a complex, dynamic ecosystem dominated …
The mechanisms by which apolipoprotein L1 (APOL1) risk variants, G1 and G2, induce kidney disease in individuals of African ancestry remain contentious.
Deep endometriosis (DE) is the most severe subtype of endometriosis, marked by aggressive cellular behavior and debilitating pain. However, the molecular mechanisms underlying DE pathogenesis remain poorly understood. In this …
Intrauterine adhesions (IUA) and endometriosis are debilitating gynecological disorders that impair endometrial function and fertility. IUA, typically caused by iatrogenic trauma to the basal endometrium, leads to fibrosis and infertility, …
Endometriosis is a chronic inflammatory disease with cancer-like features, yet the mechanisms linking metabolic dysregulation to immune remodeling during lesion progression remain poorly understood. Here, we identify the ubiquitin E3 …