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Effects of hormonal treatment on the expression of collagen type I, matrix metalloproteinase-1, and tissue inhibitor of metalloproteinases-1 in endometriosis.

Endometriosis is an estrogen-dependent disease, and hormonal treatment is the most common treatment. Both deep infiltrating endometriosis (DIE) and ovarian endometrioma (OV) are characterized by dense surrounding fibrotic tissue. However, …

Published: Oct. 24, 2025, midnight
HMGB-1 Increases Proinflammatory Reaction via TLR4 in Human Granulosa Cells of Endometriosis.

Background/Objectives: Oxidative stress is a critical factor in the development and progression of endometriosis. Granulosa cells, which reside near oocytes in follicles, exhibit steroidogenic activity, and, consequently, influence oocyte quality. …

Published: Oct. 24, 2025, midnight
Targeting Steroid Receptor Coactivators for the Treatment of Benign Female Reproductive Disorders.

Steroid receptor coactivators (SRCs) are master regulators of nuclear receptor signaling and play essential roles in female reproductive physiology. By integrating steroid hormone signaling with growth factors and metabolic pathways, …

Published: Oct. 23, 2025, midnight
Honokiol inhibits cell migration and invasion by blocking EMT via Snail/Slug axis in endometriosis.

Endometriosis, a common gynecological disease, leads to dysmenorrhea and infertility. EMT process was closely related to the pathology of endometriosis. More therapies were required to be explored for endometriosis management. …

Published: Oct. 22, 2025, midnight
Digital Health Technologies in the Treatment of Chronic Pelvic Pain Syndromes: A Systematic Review of Randomized Clinical Trials.

Objective: To comprehensively examine the qualitative results of current studies reporting the efficacy of digital health (DH) technologies in the treatment of chronic pelvic pain syndromes (CPPS) and to describe …

Published: Oct. 22, 2025, midnight
IL-6 Inhibits Invasion in a Murine Model of Endometriosis.

Endometriosis is a gynecological inflammatory disorder characterized by the presence of endometrial tissue outside of the uterus. It affects 10-15% of reproductive aged women, causing pelvic pain and infertility. Existing …

Published: Oct. 21, 2025, midnight
'En bloc' peritoneal mesometrial resection (PMMR) and pelvic targeted compartmental lymphadenectomy (TCL) for management of patients with endometrial cancer - feasibility and safety study of a 'new kid on the block' in robotic surgery.

Robotic Peritoneal Mesometrial Resection and Targeted Compartmental Lymphadenectomy (PMMR + TCL) is a procedure following Cancer Field Surgery concept for endometrial cancer (EC), enabling superior locoregional control without adjuvant irradiation. …

Published: Oct. 21, 2025, midnight
Pro-endometriosis macrophage release of IL-33 is key for endometriosis pain and lesion formation.

Endometriosis is a painful gynecological inflammatory disease affecting up to 10% of females. When released by sensory neurons, calcitonin gene-related peptide (CGRP) shapes immunity, a process known as neuroimmune communication. …

Published: Oct. 21, 2025, midnight
Shaoyao Gancao Decoction: a comprehensive review of modern clinical applications and underlying pharmacological mechanisms.

Shaoyao Gancao Decoction, a classic formula from Zhang Zhongjing in the Han Dynasty, has the effects of regulating the function of the liver, relieving spasm and stopping pain. Traditionally, it …

Published: Oct. 20, 2025, midnight
[Endometriosis management in the emergency department: a diagnostic and therapeutic challenge].

Endometriosis affects at least one in ten women of childbearing age, yet it is often overlooked in emergency care. Clinicians should consider this diagnosis for any woman presenting with menstrual …

Published: Oct. 18, 2025, midnight
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