Endometriosis-derived iPSCs reveal conserved stromal maturation and endocrine responsiveness.
Endometriosis is a chronic, hormone-dependent disease characterized by altered endometrial stromal function, but mechanistic and translational studies have been hindered by the lack of tractable human models. Here, we establish …
Phenotypic Analysis of Human and Murine Endometrial Organoids using a Machine Learning Approach.
Endometrial organoids are a powerful, 3D in vitro system for studying reproductive function and disease since they are more physiologically representative than 2D cell models. However, optimal methods for the …
Identification of potent inhibitors of JUN N-terminal kinases for treatment of endometriosis and associated pain.
Endometriosis, defined as the ectopic growth of endometrial tissue outside of the uterine cavity, is an inflammatory and hormone-dependent disease that causes excruciating pelvic pain, infertility, and significantly decreases quality …