Endometriosis and adenomyosis are both characterised by ectopic endometrial-like tissue growing outside the endometrium of the uterus, however, they are ultimately distinct diseases with different pathophysiological mechanisms. Endometriosis and adenomyosis …
To explore the material basis and network mechanism of the Guizhi Fuling pills in the treatment of endometriosis and endometrial polyps based on network pharmacology and machine learning. The effective …
Adenomyosis is a heterogeneous, nonmalignant uterine disorder characterized by ectopic endometrium within the myometrium, leading to abnormal uterine bleeding, dysmenorrhea, chronic pelvic pain, and subfertility. Once considered a disease of …
The transient receptor potential melastatin 3 (TRPM3) channel is a key mediator of peripheral pain signaling, and pathogenic mutations in TRPM3 are linked to neurodevelopmental delay and epilepsy. Despite the …
Endometriosis is defined as endometrial tissue outside of the uterus. It is a debilitating, complex, and underdiagnosed condition, impacting approximately 10%-15% of reproductive-aged women worldwide. Endometriosis is associated with chronic …
Endometriosis is a chronic inflammatory, hormone dependent disorder that affects more than 200 million women worldwide. Immune dysfunction has emerged as one of the predominant mechanisms facilitating endometriosis lesion growth …
Mangroves are valuable reservoirs of diverse phytochemicals with significant therapeutic potential. Beyond their ecological roles, these bioactive compounds can influence epigenetic mechanisms, heritable changes in gene expression without alterations in …
Traditional Chinese Medicine (TCM) offers multiple advantages in the treatment of endometriosis(EMS). Bushen Wenyang Huayu Decoction (BWHD) is widely used in clinical practice for managing EMS. It can significantly alleviate …
How can the potential mechanisms and targets of endometriosis be explored through multi-omics and multi-location approaches?
Endometriosis is a benign yet invasive disease characterized by ectopic endometrial growth and immune remodeling. While emerging evidence implicates cellular senescence in disease progression, the underlying mechanisms remain largely undefined. …