Endometriosis, affecting up to 10% of women, is a chronic estrogen dependent disorder where ectopic endometrial-like tissue causes pelvic pain and infertility. Endometriosis is challenging to diagnose due to symptom …
Alessandro Santin, MD: Top takeaways from endometrial stromal sarcoma mutational analysis Contemporary OB/GYN
Infertility affects one in six individuals worldwide despite the advancement of assisted reproductive technologies. Successful embryo implantation is the first step of pregnancy, which relies on the establishment of a …
Endometriosis-associated intestinal tumors (EAITs) are rare malignancies that arise from ectopic endometrial tissue, and their clinical and molecular characteristics remain poorly defined.
Deep infiltrating endometriosis (DIE) is a severe subtype of endometriosis, often associated with dysmenorrhea and significant diagnostic challenges. Conventional biomarkers, such as cancer antigen 125 (CA125), lack sufficient specificity for …
Decidualization of human endometrial stromal cells (ESCs) precedes the successful implantation of a human embryo. Improper decidualization has been reported in numerous conditions associated with infertility including endometriosis. Multiple pathways, …
Alessandro Santin, MD, on defining molecular basis of endometrial stromal sarcoma Contemporary OB/GYN
Real-World Use of Dostarlimab Plus Chemotherapy in Advanced or Recurrent dMMR Endometrial Cancer epi-phare
Endometriosis is a chronic hormone-responsive disorder linked to infertility, usually characterized by the presence of ectopic endometrium in the pelvis that disrupts local homeostasis. Advances in single-cell "omic" methods have …