Emerging evidence suggests a genetic link between immune-related diseases and Alzheimer's disease (AD), though the underlying mechanisms remain unclear. This Mendelian randomization (MR) study investigates the genetic relationship between six …
Endometriosis is a chronic gynecologic disease of reproductive-age women, causing menstrual pain and infertility. Endocrine and inflammatory mechanisms drive its development, with estrogen/progesterone imbalance contributing to extrauterine implantation and persistence …
Endometriosis is a disease characterized by the presence of ectopic endometrium, mainly within the peritoneal cavity, and is associated with the development of inflammation due to cyclic endometrial alterations. The …
Glutamic acid decarboxylase (GAD) is vital for gamma-aminobutyric acid (GABA) synthesis. Auto-antibodies against GAD deplete GAD levels and subsequently GABA, resulting in a hyper-excitatory state. A 41-year-old woman with anti-GAD …
Endometriosis is a prevalent gynaecological disorder characterized by estrogen-dependent lesions. Pain-particularly dysmenorrhea, chronic pelvic pain, and dyspareunia-is the hallmark symptom of endometriosis. While pain mechanisms remain poorly understood, mast cells …
Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially …
Identification and Validation of Lactate-related gene signatures in endometriosis for clinical valuation and immune characterization by WGCNA and machine learning Frontiers
Endometriosis (EMS) is an oestrogen-dependent condition characterised by ectopic endometrial-like tissue growth with a chronic and inflammatory nature leading to severe symptoms and reduced quality of life. Emerging evidence implicates …
Microfibril-associated protein 2 interacts with LEF1/TCF7 and immune infiltration in uterine corpus endometrial carcinoma Termedia