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Achieving Minimal-to-No Pain in Women with Endometriosis Treated with Relugolix Combination Therapy: SPIRIT Extension Trial.

Relugolix is an oral, non-peptide gonadotropin-releasing hormone receptor antagonist administered as once-daily combination therapy (relugolix-CT; 40 mg relugolix, 1 mg estradiol, 0.5 mg norethindrone acetate) to reduce endometriosis symptoms while …

Published: Sept. 5, 2026, midnight
Elevated Neutrophil Count as a Causal Risk Factor for Endometriosis: A Mendelian Randomization Study.

Endometriosis is a chronic inflammatory gynecological disorder where immune dysregulation plays a central role in its pathogenesis. While previous observational studies have reported associations between circulating blood cell counts and …

Published: Sept. 5, 2026, midnight
Exosomal miR-22-3p targets p53 to regulate endometrial epithelial cell function in the pathogenesis of endometriosis.

Endometriosis (EMs) is a widespread gynecological disease, affecting approximately 6-10% of females of child-bearing age. Despite its significant influence on women's health, the specific pathophysiology remains unclear. The enrichment of …

Published: Sept. 4, 2026, midnight
Genetic architecture of endometriosis: risk factors, comorbidities and clinical implications.

In 1999, Dr Susan Treloar and colleagues conducted a landmark twin study in Australia and reported their estimate of 51% for the heritability of endometriosis. This important result led several …

Published: Sept. 4, 2026, midnight
Oocyte quality in endometriosis-associated infertility: a narrative analysis of mechanisms and therapeutic options.

Endometriosis is a challenging gynaecological condition that can lead to infertility. This unique narrative review summarises the impact of endometriosis, focusing on oocyte quality, its subcellular and molecular mechanisms, clinical …

Published: Sept. 3, 2026, midnight
Real-world effectiveness and tolerability of dienogest in patients with endometriosis: a cross-sectional patient-reported-study.

To evaluate the effectiveness and tolerability of dienogest in patients with endometriosis in real-world clinical practice.

Published: Sept. 3, 2026, midnight
Acute appendicitis in a patient with obstructed hemivagina and ipsilateral renal anomaly syndrome: Diagnostic overshadowing in recurrent pelvic pain.

Herlyn-Werner-Wunderlich syndrome, also known as obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome, is a rare congenital Müllerian duct anomaly, occurring in approximately 1 in 1,000,000 females. It is characterised …

Published: Sept. 3, 2026, midnight
Diagnosis and Management of Chronic Endometritis: Effects on Postoperative Pregnancy Outcomes in Endometriosis Patients with Proximal Tubal Obstruction Undergoing Hysteroscopic Tubal Catheterization and Laparoscopy.

Background: This study aims to investigate the impact of chronic endometritis (CE) diagnosis and treatment on pregnancy outcomes during hysteroscopic fallopian tube catheterization combined with laparoscopy in infertility patients with …

Published: Sept. 3, 2026, midnight
Modulating the Estrobolome and Inflammatory Microenvironment in Endometriosis: The Role of Microbiome-Targeted Interventions and Nutritional Compounds.

Endometriosis is a chronic estrogen-dependent systemic inflammatory disorder characterized by ectopic implantation of endometrial-like tissue, primarily on the ovaries, pelvic peritoneum, and bowel. According to the World Health Organization (WHO) …

Published: Sept. 3, 2026, midnight
Preoperative imaging for endometriosis awareness: an online survey study.

In 2024, an international consensus statement on non-invasive imaging techniques for the diagnosis of pelvic deep endometriosis was published, recommending transvaginal sonography as the first-line imaging modality because of cost, …

Published: Sept. 3, 2026, midnight
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