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Efficacy and Safety of Traditional Chinese Medicine Retention Enema for Endometriosis: A Systematic Review and Meta-Analysis.

Background/Objectives: Herbal retention enema is widely used in Traditional Chinese Medicine for the management of endometriosis; however, its clinical efficacy and safety have not been systematically evaluated. Methods: Ten electronic …

Causal Association Between Sleep Traits and Endometriosis: A Mendelian Randomization Study.

Previous studies suggested that irregular sleep-wake rhythms increased the risk of endometriosis. Mechanistically, sleep pattern dysregulation may promote the pathogenesis of endometriosis via neuroendocrine disturbances. However, the causal relationship between …

Effect of mindful breathing on anxiety, depression, and quality of life among women with endometriosis.

Women diagnosed with endometriosis often experience heightened anxiety, depression, and a diminished quality of life (QoL). To address these issues, mindful breathing exercises have been introduced aimed at reducing anxiety …

Aberrant Progesterone Receptor (PGR) expression is associated with Estrogen Receptor 1 (ESR1) expression in the endometrium from infertile women with endometriosis.

Estrogen receptor 1 (ESR1) and progesterone receptor (PGR) are essential regulators for endometrial receptivity and embryo implantation. Their expression is dysregulated in women with endometriosis-associated infertility. However, the relationship between …

Extrapolation of the Tinelli's Score for Vascular Involvement in Deep Endometriosis: A Case-Based Perspective.

Safety, Pharmacokinetics, and Sex Hormone Suppression of LY01021 versus Relugolix: A Single- and Multiple-Dose Escalation Study.

LY01021 is a novel oral small-molecule gonadotropin-releasing hormone (GnRH) receptor antagonist intended for the treatment of various sex hormone-dependent disorders. This study aimed to evaluate the safety, tolerability, pharmacokinetics (PK), …

Neutrophil extracellular traps in gynecological disease: pathogenic mechanisms and therapeutic opportunities.

Gynecologic disorders, including infections, sterile inflammatory diseases, endocrine abnormalities, and malignancies, share a common signature of dysregulated immunity within a uniquely hormone-responsive reproductive tract. Neutrophil extracellular traps (NETs) are increasingly …

Looking at endometriosis-diagnosis and disease mechanisms through a mechanical lens.

Endometriosis is a chronic gynecological disorder marked by the growth of endometrial-like tissue outside the uterus, often resulting in pain and infertility and affecting overall quality of life. Despite its …

Characteristics of adolescent and young adult patients undergoing surgery for deep endometriosis: a multicentre database study.

To determine the characteristics of adolescent and young adult patients undergoing surgery for severe endometriosis.

The role of Fusobacterium nucleatum in the pathogenesis of endometriosis: A microbial and microenvironmental perspective.

Endometriosis is a chronic, inflammatory gynecological condition characterized by the ectopic growth of endometrial-like tissue, with an unclear etiology and limited treatment efficacy. Recent studies implicate the oral and gut …