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The letrozole use in reproductive medicine: Beyond aromatase inhibition - a comprehensive review.

Letrozole and other aromatase inhibitors are increasingly recognized as first-line ovulation induction (OI) medications, offering an efficient and physiologic approach to ovarian stimulation that enhances outcomes in reproductive medicine. By …

Published: Feb. 17, 2026, midnight
Symptom Profiles and Anatomical Distribution of Deep Infiltrating Endometriosis.

Endometriosis is known to affect women worldwide, and most commonly involves chronic pelvic pain and infertility. Deep infiltrating endometriosis (DIE) is a condition that may involve the bladder, ureter, and …

Published: Feb. 16, 2026, midnight
Differences in response to dienogest therapy among different phenotypes of endometriosis: A single-center retrospective cohort analysis.

This study aims to investigate the differences in response to dienogest (DNG) therapy among patients with 3 different phenotypes of endometriosis: ovarian endometrioma (OMA), superficial peritoneal endometriosis (SUP), and deep …

Published: Feb. 15, 2026, midnight
Fragility Index Assessment of Randomised Trials Informing Endometriosis Management Guidance.

Published: Feb. 13, 2026, midnight
Associations of baseline characteristics, patient-reported outcomes, and satisfaction with pain therapy with the patient's global impression of change: a prospective cohort study.

Patient-reported outcome measures (PROMs) are key elements of assessing the efficacy of perioperative pain management. Here, we aimed to capture the association of 10 individually reported aspects of patient's specific …

Published: Feb. 13, 2026, midnight
From Endometriosis to Encapsulation: A Case Report of Endometriosis Causing Sclerosing Encapsulating Peritonitis.

Sclerosing encapsulating peritonitis is a rare complication of endometriosis that has sparsely been described in the literature. It involves the development of a thick gray-white fibrotic membrane, which partially or …

Published: Feb. 13, 2026, midnight
Dydrogesterone and Letrozole Combination for the Treatment of Endometriosis: A Mechanism-Based Therapeutic Approach.

Endometriosis is a complex, estrogen-dependent disease with limited effective treatments that often focus on symptom management rather than addressing the underlying pathology. Current therapies, such as progestins and GnRH agonists, …

Published: Feb. 13, 2026, midnight
Elevated CHI3L1 and COX-2 levels correlate with menstrual pain severity in endometriosis.

Endometriosis is a chronic gynecological disease associated with inflammation and severe pelvic pain in 6%-10% of women of reproductive age. Although the pathophysiology and management of endometriosis are currently understood, …

Published: Feb. 13, 2026, midnight
Impact of hormonal treatments for endometriosis on the reproductive microbiome: a systematic review.

The reproductive microbiome plays a key role in disease progression and fertility in women with endometriosis. Vaginal and endometrial dysbiosis has been increasingly linked to inflammation, impaired reproductive outcomes, and …

Published: Feb. 12, 2026, midnight
Dietary Caloric Restriction Suppresses Endometriosis by Inhibiting STAT3/ERK Pathways.

Endometriosis is a chronic, estrogen-dependent inflammatory condition that affects approximately 10% of reproductive-age women and is frequently associated with infertility and pelvic pain. Unlike many estrogen-dependent disorders, epidemiologic studies have …

Published: Feb. 11, 2026, midnight
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