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Identification of potent inhibitors of JUN N-terminal kinases for treatment of endometriosis and associated pain.

Endometriosis, defined as the ectopic growth of endometrial tissue outside of the uterine cavity, is an inflammatory and hormone-dependent disease that causes excruciating pelvic pain, infertility, and significantly decreases quality …

Published: Aug. 19, 2026, midnight
Clinical Appraisal of "Micronized Vaginal Progesterone Dose and Serum Progesterone Thresholds Determine Reproductive Outcomes in Frozen-Thawed Embryo Transfer With Hormone Replacement Therapy".

This paper critically evaluates Sekiguchi et al.'s study of vaginal progesterone dose, serum progesterone thresholds, and reproductive outcomes in hormone replacement therapy frozen embryo transfer (HRT-FET) cycles. The study conflates …

Published: Aug. 19, 2026, midnight
Time to Diagnose for Adolescent Endometriosis in West Java, Indonesia Population: A Single Centre 2 Years Retrospective Descriptive Study.

Endometriosis affects approximately 10% of reproductive-age women and up to 20% of those with infertility. Despite rising awareness in adults, adolescent endometriosis remains underrecognized, especially in Southeast Asia. This study …

Published: Aug. 19, 2026, midnight
Endometriosis-associated bone loss: re-evaluating the potential role of systemic inflammation and hypoestrogenic therapies.

Endometriosis is frequently managed with hormonal suppression that can induce hypoestrogenism during a period when many patients are still accruing peak bone mass. This narrative review summarizes current clinical and …

Published: Aug. 19, 2026, midnight
Diagnostic Accuracy of Transvaginal Ultrasound for Endometriosis Does Not Differ Between Women Undergoing Their First Versus Any Subsequent Surgical Treatment.

Australian endometriosis guidelines recommend transvaginal ultrasound (TVUS) as the first-line investigation for endometriosis. Where endometriosis has been surgically treated, there is a risk of recurrent disease and repeat surgery. It …

Published: Aug. 18, 2026, midnight
Effect of Endometriosis on Surgical Outcomes of Total Laparoscopic Hysterectomy for Benign Indications: A Propensity Score-Matched Analysis.

The objective of the study was to retrospectively evaluate the impact of endometriosis on perioperative outcomes in patients undergoing total laparoscopic hysterectomy (TLH) for benign diseases.

Published: Aug. 18, 2026, midnight
Low-cost virtual reality-based patient education for outpatient hysteroscopy: A prospective comparative observational study.

Procedural pain and pre-procedural anxiety are the most frequently cited barriers to acceptability and completion of outpatient hysteroscopy. Virtual reality (VR) offers immersive patient education, but clinical adoption has been …

Published: Aug. 18, 2026, midnight
Robotic hysterectomy and hospital performance: nationwide evidence on outcomes, efficiency, and costs in France (2020 to 2024).

Robot-assisted surgery (RAS) has increasingly been adopted for hysterectomy in France, but its impact on hospital performance according to institutional expertise remains incompletely understood. We evaluated clinical outcomes and hospital …

Published: Aug. 17, 2026, midnight
Body image concerns, disordered eating, and negative affect in women with and without gynecological conditions.

BackgroundResearch has suggested that some gynecological conditions are associated with body image, disordered eating behaviors, and mental health concerns. This has been studied in polycystic ovarian syndrome and endometriosis populations, …

Published: Aug. 17, 2026, midnight
Diet and physical activity coaching for well-being and pain reduction in patients with symptomatic endometriosis: a randomized-controlled clinical trial.

Pain is a defining symptom of endometriosis reducing quality of life and increasing the risk of psychological disorders. We conducted an open-label, randomized, controlled trial to investigate whether structured coaching …

Published: Aug. 17, 2026, midnight
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