From an immunological perspective, infertility mechanisms encompass not only fertilization but also implantation, as well as both early and late pregnancy loss. Growing attention is being directed towards the influence …
Endometriosis is a chronic, estrogen-dependent disorder influenced by both genetic and environmental factors, including endocrine-disrupting chemicals (EDCs). This study aimed to identify EDC-responsive genes contributing to endometriosis risk by integrating …
Gonadotropin-releasing hormone (GnRH) antagonists inhibit estrogen synthesis and secretion, making them promising treatment options for estrogen-dependent diseases, such as endometriosis. This study developed a population pharmacokinetic/pharmacodynamic (PK/PD) model for merigolix, …
Endometriosis (EM) affects approximately 10% of women of reproductive age and remains a prevalent estrogen-dependent gynecological disorder with limited therapeutic efficacy and high recurrence rates. Ferroptosis-an iron-dependent, non-apoptotic form of …
For many patients with endometriosis, laparoscopic surgery is the most effective treatment to alleviate severe chronic pelvic pain and improve quality of life. Because endometriosis is common among individuals with …
Endometriosis is a condition affecting approximately 10% of reproductive-age women in which endometrial tissue is found in locations outside the uterus, often causing debilitating symptoms. Aromatase, an enzyme that also …
Predominantly, case reports and small case series of endometriosis involving the bladder have been published. This study aimed to provide a contemporary clinicopathologic analysis of a large cohort of patients …
Fifteen years have elapsed since the publication of the seminal work establishing the association between risk variants in the Apolipoprotein L1 (APOL1) gene and kidney disease in individuals of African …
Endometriosis is a frequent pathology affecting approximately 10% of the general population. Its diagnosis and management have improved in recent years. In France, a national strategy against endometriosis has been …
Human papillomavirus (HPV) is a well-established etiological agent for cervical cancer, yet its contribution to endometrial malignancies remains underrecognized and mechanistically distinct. This paper synthesizes current evidence to explain the …