β-Glucuronidase (β-G, EC 3.2.1.31) reverses phase II glucuronidation, and microbial β-G at the gut-liver interface reactivates biliary and circulating conjugates, closing enterohepatic loops for drugs, estrogens, bile acids, and bilirubin. …
Endometriosis is a complex chronic inflammatory disease with an unclear etiology and limited treatment options, severely affecting the reproductive health and quality of life of many women. Histone deacetylases (HDACs), …
Endocrine-disrupting chemicals (EDCs) are ubiquitous environmental contaminants that interfere with hormone signalling and are increasingly linked to adverse reproductive outcomes. This viewpoint highlights emerging evidence that EDC exposure disrupts both …
Relugolix is an oral, non-peptide gonadotropin-releasing hormone receptor antagonist administered as once-daily combination therapy (relugolix-CT; 40 mg relugolix, 1 mg estradiol, 0.5 mg norethindrone acetate) to reduce endometriosis symptoms while …
Social media has emerged as a valuable source of patient-generated data, offering insights into the lived experiences of individuals with endometriosis. While social listening research provides important perspectives on pain, …
Rural, regional and remote (henceforth 'rural') communities face unique health challenges, including limited access to health care, workforce shortages, and higher disease burden. Consumer and community involvement is essential for …
Hepatic endometriosis is a rare extrapelvic manifestation that can mimic hepatic neoplasia and, exceptionally, cause hemoperitoneum. We report a 45-year-old nulligravid woman with longstanding deep endometriosis and anticoagulation for cavoiliac …
Endometriosis (EuE) is a chronic, incurable disease. Due to limited efficacy, high recurrence rates, and serious side effects of current treatments, development of new, targeted, nonhormonal therapies is urgently needed. …
Endometriosis is a chronic, estrogen-dependent inflammatory condition affecting approximately 10% of women of reproductive age and manifesting with pelvic pain, dysmenorrhea, dyspareunia, fatigue, and infertility. First-line treatment in most patients …
Pelvic magnetic resonance imaging (MRI) plays an important role in the evaluation of suspected gynecologic malignancies, providing high soft tissue contrast and multiparametric capabilities, including diffusion-weighted imaging and dynamic contrast …