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The interplay between migraine, endometriosis and polycystic ovarian syndrome: A systematic review.

BackgroundMigraine and gynecological conditions, such as endometriosis (EDM) and polycystic ovarian syndrome (PCOS), are highly prevalent among females and appear to influence each other, with a potential shared pathophysiological mechanism. …

Published: Dec. 12, 2025, midnight
Impact of Physical Rehabilitation on Endometriosis and Adenomyosis-Related Symptoms: A Systematic Review and Meta-Analysis.

Objectives: The aim of this study is to summarize recent evidence of the effectiveness of rehabilitation interventions in managing symptoms related to endometriosis and adenomyosis. Methods: The review protocol was …

Published: Nov. 21, 2025, midnight
Endometriosis lesion growth inhibition and immune modulation function of thymol in vitro and in vivo.

Thymol, a phenolic monoterpene derivative found in the essential oil of Thymus vulgaris L., Lamiaceae, is currently under investigation for potential applications in pharmaceuticals, functional foods, and cosmetics. Despite ongoing …

Published: Nov. 17, 2025, midnight
Urogynecological Outcomes After Minimally Invasive Surgery for Deep Endometriosis: A Systematic Review.

Deep endometriosis (DE) frequently affects pelvic organs and may impair urinary function through both direct involvement and surgical nerve disruption. Minimally invasive excision is the standard treatment for symptomatic DE, …

Published: Nov. 17, 2025, midnight
Integrated bioinformatics analysis and machine learning identifies FZD4, SRPX2, and COL8A1 as angiogenesis hub genes in endometriosis.

This study aims to identify angiogenesis-associated genes (AAGs) in endometriosis (EM) by integrating bioinformatics analysis with machine learning, and to investigate their underlying mechanisms. Differentially expressed genes (DEGs) were screened …

Published: Oct. 26, 2025, midnight
Exploring the Early Endometrial-Blastocyst Interactome in Endometriosis: An Integrative Study.

Background: Background: Endometriosis affects 10% of women of reproductive age. Despite the well-known association between endometriosis and infertility, the mechanisms underlying this association remain to be elucidated. Methods: Implantation and …

Published: Oct. 23, 2025, midnight
SPP1 as a key modulator of M2 macrophage polarization promotes endometriosis progression via activation of the FAK/PI3K/AKT pathway: A bioinformatics and experimental study.

Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially …

Published: Sept. 17, 2025, midnight
AntiCD44 antibody-conjugated gold nanoparticles for targeted photothermal therapy of endometriotic cells.

Endometriosis is a chronic gynecologic disease that needs newer and safer treatments. The proposed work aims to develop a nanosystem based on gold nanoparticles (AuNPs) to actively target human endometriosis …

Published: Aug. 13, 2025, midnight
IVF/ICSI or surgery as first approach for the treatment of infertility associated with ovarian and deep infiltrating endometriosis? A systematic review and meta-analysis.

This systematic review and meta-analysis (CRD42024588171) compared the effectiveness of surgery followed by IVF/intracytoplasmic sperm injection (IVF/ICSI) with direct IVF/ICSI (i.e. without previous surgery) on the reproductive outcomes of infertile …

Published: July 29, 2025, midnight
Association between endometriosis and endometrial polyps: a systematic review and meta-analysis.

Endometriosis and endometrial polyps are oestrogen-dependent conditions that frequently co-occur, yet their combined prevalence remains unclear. This study synthesized data on the prevalence of endometrial polyps in women with endometriosis …

Published: June 22, 2025, midnight
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