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Deciphering the Role of ZEB1 as a Central Regulator of Epithelial-Mesenchymal Transition and Hormonal Resistance in Endometriosis.

Endometriosis is a chronic inflammatory and sex steroid hormone-dependent gynaecologic disease, characterised by endometrial cell proliferation outside the uterine cavity, often accompanied by fibrosis, progesterone resistance, and high recurrence despite …

Published: Sept. 9, 2026, midnight
Research Progress of Autophagy and Ferroptosis in Endometriosis.

Endometriosis (EMs) is a common and refractory disease in clinical practice.It has the pathological characteristics of adhesion and invasion,while the pathogenesis remains unclear.In recent years,studies have found that autophagy and …

Published: Aug. 29, 2026, midnight
Endothelial cell heterogeneity drives angiogenesis in endometriosis: mechanisms and emerging organoid-based models.

Endometriosis (EMs) is characterized by the establishment and persistence of ectopic lesions, a process fundamentally dependent on aberrant angiogenesis. Endothelial cells (ECs) play a central role in this process; however, …

Published: Aug. 20, 2026, midnight
A distinct Frequency of Endometrial Stem/Progenitor Cells (EnSCs) in the Ectopic and Eutopic Endometrium of Women with Endometriosis.

Endometriosis is a chronic estrogen-dependent disorder characterised by the growth of endometrial-like tissues outside the uterus. Recent data suggest a potential role for endometrial stem/progenitor cells in the development of …

Published: Aug. 19, 2026, midnight
Exosomal miR-21-5p from ectopic endometrial stromal cells drives fibrosis progression in endometriosis through direct VHL targeting.

Ovarian endometriosis is a chronic inflammatory disease characterized by extensive tissue remodeling and fibrosis, which significantly impacts female reproductive health. This study demonstrates that ectopic endometrium (Ect) in patients with …

Published: Aug. 12, 2026, midnight
TREM2 Deficiency Attenuates Endometriosis Progression by Inhibiting M2 Polarization of SpMs and Suppressing SIRPα to Enhance Phagocytosis.

Endometriosis (EMS) is characterised by a disrupted peritoneal immune microenvironment where M2 macrophage polarization and impaired phagocytosis promote lesion survival. Single-cell RNA-seq (ScRNAseq) of the peritoneal macrophages from EMS patient …

Published: Aug. 5, 2026, midnight
Low-energy extracorporeal shock wave therapy is associated with reduced inflammation and fibrosis in an E2-induced rat model of endometriosis and remains effective under menopause-mimicking conditions.

Endometriosis is an estrogen-dependent inflammatory disorder marked by ectopic lesions, chronic pelvic inflammation, and frequent recurrence. Extracorporeal shock wave therapy (ESWT) is a non-invasive modality with anti-inflammatory and regenerative potential, …

Published: Aug. 3, 2026, midnight
Expression Profiling of Immune-Related Genes in Different Samples from Patients with Endometriosis Revealed Upregulation of THBS1, CHGB and CYR61.

Endometriosis is a chronic, inflammatory, estrogen-dependent disease that affects approximately 6-10% of women of reproductive age. The present study aimed to investigate the expression of 48 immune-related genes in different …

Published: Aug. 1, 2026, midnight
NLRP3/Caspase-1-Mediated Pyroptosis Drives a Brain-Lesion Neuroimmune Axis in Endometriosis-Associated Pain: Molecular Mechanisms and Transcranial Direct Current Stimulation Intervention.

Background/Objectives: The NLRP3 inflammasome-Caspase-1-IL-1β pyroptotic axis participates in peripheral inflammatory responses, yet its function in peripheral-central neuroimmune crosstalk underlying endometriosis (EM)-associated pain remains unclear. This study aimed to clarify whether …

Published: July 30, 2026, midnight
Hierarchical attention and frequency fusion network for endometriotic lesion detection in laparoscopic images.

Endometriosis is a common gynecological disorder that requires accurate detection of ectopic lesions in laparoscopic images for effective diagnosis and treatment. However, existing deep learning-based detection methods face significant challenges …

Published: July 23, 2026, midnight
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