From polygenic risk to functional genomics: a framework for precision gynecological disease modeling.
Gynecological conditions including endometriosis, polyendocrine metabolic ovarian syndrome and malignancies cause widespread chronic morbidity and infertility, yet translating genetic discoveries into biological mechanisms remains challenging. We propose a framework integrating …
Single-cell Transcriptomic Atlas of Ovarian Endometriosis Patient's Follicular Fluid: Unraveling Novel Insights into Abnormal Follicular Development.
Ovarian endometrioma (OMA), an endometriosis subtype, involves hemorrhagic cysts formed by ectopic endometrial-like tissue, causing pelvic pain, inflammation, and infertility by disrupting ovarian function. Despite its impact, the single-cell dynamics …