Gynecological conditions including endometriosis, polyendocrine metabolic ovarian syndrome and malignancies cause widespread chronic morbidity and infertility, yet translating genetic discoveries into biological mechanisms remains challenging. We propose a framework integrating …
Endometriosis is a chronic, hormone-dependent disease characterized by altered endometrial stromal function, but mechanistic and translational studies have been hindered by the lack of tractable human models. Here, we establish …
Patient-derived organoids (PDOs) have emerged as physiologically relevant three-dimensional (3D) culture systems that closely mimic the molecular and histological features of the human endometrium and associated malignancies. Owing to their …
This review aims to evaluate the potential of endometriosis models, especially patient-derived iPSC models, to gain deeper insights into the disease, thereby advancing our understanding and treatment of endometriosis. This …
Ovarian endometriosis is an estrogen-dependent inflammatory disorder in which endometrial stromal cells are key cellular contributors to hormone-immune crosstalk and lesion persistence. Here, we isolated paired eutopic (NESC) and ectopic …
Endometriosis is a chronic, estrogen-dependent disorder defined by ectopic endometrial-like tissue growth, persistent inflammation, and aberrant innervation. Emerging evidence indicates that disease progression and symptom severity are driven by a …
The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for …
Endometriosis affects approximately 10% of reproductive-age women and is associated with genomic instability; however, the contribution of specific DNA repair deficiencies remains poorly understood. This study investigated the expression and …
Scientists Develop a New Patient-Derived Organoid Model for Studying Endometriosis Subtypes Physicians Committee for Responsible Medicine
Endometriosis is a common gynecological disease associated with pelvic pain and infertility. Despite several existing theories, the etiology and molecular mechanisms of endometriosis remain to be investigated. Here we report …