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Systems-level genomic analyses reveal shared mechanisms underlying endometriosis and sleep disorders.

We examined clinical, genetic, and molecular links between sleep disorders and endometriosis. Women aged 20-54 years in NHANES 2005-2006 were analyzed with survey-weighted logistic regression. Bidirectional two-sample Mendelian randomization (MR) …

Endometriosis: imaging spectrum of unusual locations and atypical presentations.

Endometriosis is a chronic, estrogen-dependent inflammatory disease defined by the presence of endometrial-like tissue outside the uterus, affecting approximately 10% of women of reproductive age as well as a notable …

Indications and Efficacy of Progestogen-Monotherapy as Menopause Hormone Therapy: A Narrative Review.

Menopausal hormone therapy (MHT) remains the most effective treatment for vasomotor symptoms (VMS) and other manifestations of menopause; however, its use is limited in women with contraindications to oestrogen. Progestogen …

Multimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care.

Chronic overlapping pain conditions (COPCs) refer to a set of chronic pain disorders that frequently co-occur and may involve partially overlapping mechanisms. The U.S. National Institutes of Health currently recognizes …

A Rare Coexistence: Uterine Leiomyoma Arising in a Mature Cystic Teratoma and a Pedunculated Endometriotic Cyst Mimicking Leiomyoma-Two Case Reports.

Uterine leiomyomas are common benign tumors, but their clinical presentation can be misleading. We report two unusual cases of pedunculated uterine masses presenting with heavy vaginal bleeding. In the first …

Mullerian Adenosarcomas with Extrauterine Involvement, Sarcomatous Overgrowth and MDM2 Amplification: A Diagnostic Challenge.

Extrauterine presentation of Mullerian adenosarcoma is rare and thought to either arise from endometriosis or from spread from a primary uterine or ovarian origin. When accompanied by sarcomatous overgrowth, particularly …

Associations between physical activity, sleep patterns and diet quality and menstrual health symptoms in midlife: evidence from the 1970 British Cohort Study.

Menstrual health symptoms, including painful periods, heavy bleeding, and premenstrual syndrome (PMS), are prevalent in midlife women and may be influenced by lifestyle factors. Identifying modifiable health behaviours associated with …

Selected Parameters of the Mental State of Women with Endometriosis-A Systematic Review.

Background: Endometriosis is a chronic, estrogen-dependent inflammatory disorder affecting millions of women worldwide and constitutes a major cause of chronic pelvic pain and reduced quality of life. Increasing evidence suggests …

Expression of concern to "Evaluation of depression and sleep disorders in the preoperative and postoperative period in stage 4 endometriosis patients" [Eur. J. Obstet. Gynecol. Reprod. Biol. 264 (2021) 254-258].

Is endometriosis associated with poor sleep quality? A meta-analysis.

BackgroundEndometriosis is a hormone-driven systemic inflammatory condition characterized by endometrial-like lesions which grow throughout the body affecting up to 15% of women worldwide with symptoms including chronic pain, infertility, and …