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Evidence-based recommendations for advancing the chronic pelvic pain syndrome management by the paradigm change from reactive symptom suppression to proactive 3PM-guided patient-centered care.

Chronic pelvic pain syndrome (CPPS) encompasses a heterogeneous group of debilitating conditions including interstitial cystitis/bladder pain syndrome (IC/BPS), chronic abacterial prostatitis, endometriosis, and pelvic congestion syndrome, among others. Despite advances …

Published: Aug. 28, 2026, midnight

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Chronic abacterial prostatitis Chronic pelvic pain syndrome Chronic sterile inflammation Digital health monitoring Holistic approach Homeostasis and biosensorics Interstitial cystitis & bladder pain syndrome Microbiome Multi-factorial disease Nutraceuticals Pain chronification Patient phenotyping and stratification Poor outcomes by reactive care Predictive preventive personalized medicine (PPPM / 3PM) Sympathetic overdrive syndrome (SOP) Systemic mitochondrial stress TRP channels Tear fluid-based diagnostics Therapy-resistant prostate cancer Treatments tailored to individualized patient profiles Vaginal dryness

TRPM3 mediates spontaneous pain and mechanical allodynia in a mouse model of chronic orofacial neuropathy.

Trigeminal nerve injury can lead to chronic and difficult-to-treat orofacial neuropathic pain. Here, we uncover a key role for the cation channel TRPM3 in the chronic constriction injury of the …

Published: March 9, 2026, midnight

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TRP channels TRPM3 neuropathic pain trigeminal neuron

Latest Articles

Evidence-based recommendations for advancing the chronic pelvic pain syndrome management by the paradigm change from reactive symptom suppression to proactive 3PM-guided patient-centered care.

TRPM3 mediates spontaneous pain and mechanical allodynia in a mouse model of chronic orofacial neuropathy.

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