It is critical that women undertaking medically assisted reproductive (MAR) treatment and their clinicians know whether the treatments are associated with an increased risk of hormone-related cancers.
Women remain underrepresented in clinical drug development despite their unique biological characteristics and growing disease burden. In China, this disparity is particularly concerning given the rising incidence of gynecologic conditions …
This systematic review and meta-analysis of randomized controlled trials (RCTs) evaluated whether the use of hyaluronic acid (HA)-enriched medium for embryo transfer (ET) improves live birth rates in in-vitro fertilization …
Goserelin is a gonadotropin-releasing hormone (GnRH) agonist with a long history of clinical application and well-established efficacy and safety profile. Its mechanism of action centers on sustained GnRH receptor desensitization, …
Mycotoxins are widespread food contaminants, and urinary biomarkers reflect recent dietary exposure. Although mycotoxins have been implicated in reproductive toxicity, their impact on human oocyte and embryo development remains poorly …
To assess whether pre-existing endometriosis is associated with specific adverse pregnancy and delivery outcomes in primiparous women.
Nerve Growth Factor (NGF), a member of the neurotrophin family, is currently regarded as a key regulator of ovarian physiology beyond its well-known neurotrophic functions. The mammalian ovary is one …
Vitamin D a fat-soluble steroid hormone signals through Vitamin D Receptors (VDRs) located throughout the ovaries, uterus, placenta, hypothalamus, and pituitary gland, influencing immune regulation and female reproductive physiology. This …
Reproductive health unfolds across the lifespan, and individuals may move through diverse pathways - including infertility, chronic gynecologic conditions such as endometriosis, pregnancy complications, assisted reproduction or gestational carriage. These …
Ovarian function relies on a network of well-coordinated molecular mechanisms that regulate follicular development, oocyte maturation, ovulation, and corpus luteum function. When these processes are disrupted, infertility can result. Extracellular …