Mendelian Randomization Analysis of the Relationship Between Immune-Related Diseases and Alzheimer's Disease.
Emerging evidence suggests a genetic link between immune-related diseases and Alzheimer's disease (AD), though the underlying mechanisms remain unclear. This Mendelian randomization (MR) study investigates the genetic relationship between six …
Design of a peripherally biased NPSR1 antagonist for neuropeptide S induced inflammation.
Neuropeptide S (NPS) is a potent agonist for the GPCR receptor NPSR1, implicated in various physiological and pathological processes, including inflammation. NPSR1 gene polymorphisms have been linked to asthma, inflammatory …
Unveiling the connection: asthma and endometriosis - a comprehensive systematic review and meta-analysis.
Asthma and endometriosis are two prevalent chronic conditions that affect a significant portion of the population. Both conditions have been linked to inflammatory processes and immune dysregulation, suggesting the possibility …
Thymic stromal lymphopoietin contributes to endometriotic lesion proliferation and disease-associated inflammation.
Endometriosis is a chronic disorder in which endometrial-like tissue presents outside the uterus. Patients with endometriosis have been shown to exhibit aberrant immune responses within the lesion microenvironment and in …