Endometriosis is a chronic inflammatory gynecological disorder where immune dysregulation plays a central role in its pathogenesis. While previous observational studies have reported associations between circulating blood cell counts and …
Observational studies have reported comorbidity between autoimmune thyroid disease and endometriosis, but whether this reflects a direct causal relationship or shared susceptibility remains unclear. We evaluated the bidirectional relationship between …
Background/Objectives: Endometriosis is a chronic estrogen-dependent disease with a complex and incompletely understood etiology. Environmental exposure to toxic elements, including cadmium, lead, mercury, and arsenic, may contribute to its development …
Endometriosis (EMS) and inflammatory bowel disease (IBD) are both chronic inflammatory disorders with overlapping clinical features, suggesting a potentially shared etiology. Although epidemiological studies have reported an association between the …
Orofacial pain (OFP) is a multidimensional clinical problem that includes conditions such as temporomandibular disorders (TMD). It is often associated with chronic overlapping pain conditions (COPCs), including gastrointestinal, gynecological and …
Endometriosis (EMS) is a chronic inflammatory disease defined by the presence of endometrial-like tissue outside the uterine cavity. Ovarian EMS is considered the most prevalent disease phenotype. However, the causal …
Accumulating observational evidence suggests an association between thyroid function and endometriosis, though the causal relationship remains unclear. To investigate potential bidirectional causal relationships, including for endometriosis subtypes, we conducted a …
Polyunsaturated fatty acids (PUFAs) are hypothesized to modulate female reproductive endocrine disorders, yet their causal relationships remain elusive. We employed Mendelian randomization (MR) to investigate bidirectional causality between circulating PUFAs …
Endometriosis is a prevalent gynecologic disorder that significantly impacts women's health. However, its underlying pathogenesis remains unknown. This study aimed to ascertain causal associations between plasma protein levels and endometriosis …
The comorbidity between endometriosis and migraine has long been recognized clinically, yet a unifying pathophysiological explanation has remained elusive. Traditional models, centered on hormonal fluctuations or secondary inflammation are lacking …