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Identifying Novel Biomarkers and Therapeutic Targets for Endometriosis: Integrative Analysis of the Plasma Proteome and Genome.

There is currently no consensus on the etiology, pathogenesis, or treatment of endometriosis (EM). The discovery of disease-associated plasma proteins with causal genetic evidence provides an opportunity to identify new …

Published: May 24, 2026, midnight
Association between circulating metabolites and endometriosis: a bidirectional two-sample Mendelian randomization study.

Endometriosis (EM) is a chronic gynecological condition of unclear etiology, with evidence suggesting a link between metabolite levels and EM risk. A two-sample Mendelian randomization (MR) approach was used to …

Published: May 6, 2026, midnight
Current methods and mechanisms for animal models of pelvic inflammatory disease: a review.

Pelvic inflammatory disease (PID) is a complex multifactorial infectious disorder of the female reproductive tract, associated with severe long-term sequelae including infertility, ectopic pregnancy, and chronic pelvic pain, as well …

Published: May 1, 2026, midnight
Microecological modulators-new perspectives for treating sex hormone disorders.

Sex hormone related disorders, characterized by complex etiology and long-term health risks, pose a significant challenge to global health. Hormone-based therapies are often accompanied by adverse effects and fail to …

Published: April 30, 2026, midnight
A meta-umbrella review of risk factors for vulvodynia: evidence from demographic, psychosocial, and biomedical domains.

Vulvodynia is a chronic vulvar pain condition significantly affecting the quality of life. Its multifactorial etiology is not fully understood, and comprehensive pooled data on associated risk factors are lacking …

Published: March 25, 2026, midnight
TCF21 promotes epithelial-to-mesenchymal transition and cytoskeleton reorganization in uterine development and endometriosis.

Endometriosis is a common gynecological disease associated with pelvic pain and infertility. Despite several existing theories, the etiology and molecular mechanisms of endometriosis remain to be investigated. Here we report …

Published: March 5, 2026, midnight
DRIVE-KG: Enhancing variant-phenotype association discovery in understudied complex diseases using heterogeneous knowledge graphs.

Multi-omics data are instrumental in obtaining a comprehensive picture of complex biological systems. This is particularly useful for women's health conditions such as endometriosis, which has been historically understudied despite …

Published: Feb. 28, 2026, midnight
Dynamics of diaphragmatic endometriosis with thoracic endometriosis-related pneumothorax.

Pneumothorax that occurs during menstruation is called catamenial pneumothorax; however, it is also called thoracic endometriosis-related pneumothorax (TERP) because of its etiology. Because of its high postoperative recurrence rate, TERP …

Published: Feb. 25, 2026, midnight
The role of gut microbiota in modulating estrogen in the inflammatory milieu of endometriosis: A molecular and pathophysiological perspective.

Endometriosis is a prevalent estrogen-dependent chronic inflammatory condition that affects millions of women of reproductive age worldwide. It is characterized by the growth of endometrial tissue outside the uterine cavity, …

Published: Feb. 24, 2026, midnight
Uterine Arteriovenous Malformations: An Underrecognized Putative Cause of Postpartum Hemorrhage, Abnormal Uterine Bleeding, and Pelvic Pain.

Arteriovenous malformations (AVMs) are vascular anomalies defined by direct communications between arteries and veins with bypassing of the capillary network. Such lesions may be congenital or acquired. In the uterus, …

Published: Feb. 20, 2026, midnight
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