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Exploring the mechanism of plastic additives on reproductive disorders based on network toxicology and molecular docking.

Phthalate esters (PAEs) and organophosphate esters (OPEs) are pervasive 20 environmental pollutants with endocrine-disrupting properties. Despite growing 21 evidence linking PAE/OPE exposure to female reproductive disorders, the 22 diseasespecific molecular …

Published: May 14, 2026, midnight
TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour.

Female fertility relies heavily on the health of the oviduct and uterus. Each of these organs consist of a muscular tube lined by epithelial cells. In this review, we discuss …

Published: May 13, 2026, midnight
Use of artificial neural network optimization for MHD and non-Newtonian peritoneal Jeffery nanofluid dynamics on female reproductive health.

The dynamics of peritoneal fluid has vital applications in various physiological functions, particularly in female reproductive physiology, which modulates the transport of gametes within the fallopian tubes. This research aims …

Published: May 12, 2026, midnight
Current methods and mechanisms for animal models of pelvic inflammatory disease: a review.

Pelvic inflammatory disease (PID) is a complex multifactorial infectious disorder of the female reproductive tract, associated with severe long-term sequelae including infertility, ectopic pregnancy, and chronic pelvic pain, as well …

Published: May 1, 2026, midnight
Transfer RNA-derived small RNAs in female reproductive disorders: emerging roles and clinical implications.

Female reproductive disorders present significant challenges worldwide. Transfer RNA-derived small RNAs (tsRNAs), a structurally diverse class of non-coding RNAs mainly comprising tRNA halves (tiRNAs) and tRNA-derived fragments (tRFs), have emerged …

Published: April 29, 2026, midnight
Endocrine roles of vitamin D in female reproduction: Mechanisms and clinical implications.

Vitamin D a fat-soluble steroid hormone signals through Vitamin D Receptors (VDRs) located throughout the ovaries, uterus, placenta, hypothalamus, and pituitary gland, influencing immune regulation and female reproductive physiology. This …

Published: April 27, 2026, midnight
Cell-free regenerative therapies for female infertility: The emerging role of mesenchymal stem cell secretome.

Female reproductive disorders are a leading cause of infertility, affecting millions of women worldwide and resulting in significant emotional and social challenges. Despite advances in medical science, current treatment options …

Published: April 22, 2026, midnight
Obstructive Sleep Apnea and Female Reproductive Endocrine Diseases: A Mendelian Randomization and Mediation Analysis.

This study aimed to evaluate the potential causal association between obstructive sleep apnea (OSA) and the risk of female reproductive endocrine diseases (REDs), including polycystic ovary syndrome (PCOS), endometriosis (EMs), …

Published: April 16, 2026, midnight
Novel insights into the role of Annexin A2 signaling pathway in female reproductive system diseases: from mechanisms to advanced therapies.

Annexin A2 (ANXA2) is a calcium-dependent protein with high affinity for phospholipids, and its multifunctional nature has drawn increasing attention in the onset and progression of various disorders of the …

Published: April 14, 2026, midnight
Unravelling Multilayered RNA Modification Networks in Female Reproduction and Obstetric/Gynaecologic Disorders.

Background/Objective: RNA modifications, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), 7-methylguanosine (m7G), N1-methyladenosine (m1A), pseudouridine (Ψ), N4-acetylcytidine (ac4C), 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) and adenosine-to-inosine (A-to-I) editing, constitute a critical layer of post-transcriptional regulation that …

Published: April 13, 2026, midnight
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