Latest Articles

Evaluation of angiopoietin-like protein 4 levels in patients with endometriosis.

Endometriosis is a chronic inflammatory disorder lacking definitive laboratory diagnostic markers. Angiopoietin-like protein-4 (ANGPTL4) is a protein involved in the regulation of angiogenesis and inflammation. The aim of the present …

Human peritoneal hypoxia may stabilize rather than initiate endometriotic lesions.

Hepatic endometriosis causing hemoperitoneum in a woman with deep endometriosis.

Hepatic endometriosis is a rare extrapelvic manifestation that can mimic hepatic neoplasia and, exceptionally, cause hemoperitoneum. We report a 45-year-old nulligravid woman with longstanding deep endometriosis and anticoagulation for cavoiliac …

2-Deoxyglucose Dendrimer-Enabled Niclosamide Delivery to FRβ-Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia.

Endometriosis (EuE) is a chronic, incurable disease. Due to limited efficacy, high recurrence rates, and serious side effects of current treatments, development of new, targeted, nonhormonal therapies is urgently needed. …

Endometriosis risk factors and comorbidities by endometriosis lesion macrophenotypes: An analysis from the What is Endometriosis (WisE) study.

While endometriosis is thought to be a heterogeneous disease, the pathophysiologic heterogeneity across the three visualized lesion macrophenotypes (i.e., superficial peritoneal endometriosis(SPE) lesions, endometriomas, and deep lesions) remains unclear.

Endometriosis-related peritoneal adhesion formation: molecular mechanisms and clinical significance.

Peritoneal adhesions are a major and often under-recognized cause of morbidity following abdominopelvic inflammation and surgery, contributing to chronic pelvic pain, infertility, bowel obstruction, and surgical complications. Endometriosis, affecting 10-11% …

Elevated interleukin-33, CD1c+ dendritic cells, and interleukin-17A in peritoneal fluid of patients with endometriosis: a case-control study.

Endometriosis (EMS) is a chronic inflammatory disorder involving ectopic endometrial tissue growth. This study investigated IL-33, CD1c+ dendritic cells (DCs) and their co-stimulatory molecules (CD40, CD80, CD86), and IL-17 A …

Stage-dependent shifts in peritoneal cytokine profiles drive monocyte functional reprogramming in endometriosis.

Introduction. Endometriosis is a chronic inflammatory disease in which monocytes/macrophages play a key pathogenetic role. The peritoneal fluid (PF) cytokine profile can modulate recruited monocyte functions, determining their contribution to …

Integrated lipidomics and transcriptomics reveal the key role of ceramides in the development of endometriosis.

Endometriosis (EMs) is a chronic gynecological disease with poorly understood pathogenesis. This study integrated lipidomics and transcriptomics to systematically investigate aberrant sphingolipid metabolism in EMs, aiming to identify pathogenic mechanisms …

Do Oxidative Stress-Modified Exosomes Contribute to Infertility in Endometriosis?

Endometriosis affects approximately 10% of women of reproductive age and is associated with infertility in up to half of those diagnosed. Despite decades of research, the molecular basis of its …