There is currently no consensus on the etiology, pathogenesis, or treatment of endometriosis (EM). The discovery of disease-associated plasma proteins with causal genetic evidence provides an opportunity to identify new …
Endometriosis, affecting 1 in 9 women, presents treatment and diagnostic challenges. To address these issues, we generated a comprehensive single-cell atlas of endometrial tissue, comprising 466,371 cells from 35 endometriosis …
Endometriosis is a benign yet aggressive disease characterized by enhanced proliferation and invasion of ectopic endometrial tissue. Identifying upstream regulators that co-regulate these processes will provide novel insights into endometriosis …
Endometriosis (EM) is a prevalent gynecological disorder linked to pelvic pain, menstrual disturbances, and infertility. Despite its clinical burden, the molecular mechanisms underlying EM remain elusive, necessitating the discovery of …
Endometriosis is a prevalent inflammatory disease affecting approximately one in ten women, characterized by endometrial tissue outside the uterus. Despite its high incidence, treatment options are limited, and the underlying …
Endometriosis (EM) is driven by immune dysregulation and macrophage dysfunction, yet the underlying mechanisms remain unclear. Here, metabolomic profiling revealed excessive itaconate accumulation in EM lesions, primarily due to elevated …
Background/Objectives: Endometriosis is a prevalent gynecological illness associated with chronic pain, inflammation, and infertility, as ectopic endometrial lesions are formed. No fully effective treatment is available, and the pathogenesis of …
Endometriosis is a chronic, estrogen-dependent disorder influenced by both genetic and environmental factors, including endocrine-disrupting chemicals (EDCs). This study aimed to identify EDC-responsive genes contributing to endometriosis risk by integrating …
Endometriosis is a chronic inflammatory disorder with poorly understood mechanisms. Inflammatory proteins are hypothesized to play a causal role, but evidence remains limited. We performed a 2-sample Mendelian randomization study …
Endometriosis represents a prevalent gynaecological disorder, impacting around 10% of the female population and affecting as many as 50% of women who are facing challenges with infertility. The pathogenesis of …