Latest Articles

Three- and Four-Dimensional Pelvic Floor Ultrasound in Chronic Pelvic Pain: Evidence, Technical Considerations, and a Proposed Framework.

Chronic pelvic pain (CPP) is a heterogeneous condition in which visceral, musculoskeletal, neuropathic, and pain-processing contributors often overlap. Pelvic floor ultrasound can depict morphology and movement, but its CPP-specific evidence …

Endothelial cell heterogeneity drives angiogenesis in endometriosis: mechanisms and emerging organoid-based models.

Endometriosis (EMs) is characterized by the establishment and persistence of ectopic lesions, a process fundamentally dependent on aberrant angiogenesis. Endothelial cells (ECs) play a central role in this process; however, …

A 3D PDMS Scaffold Microchip Platform for Non-Invasive Detection of Circulating Endometrial Cells: Revolutionizing Endometriosis Diagnosis.

To address the urgent need for non-invasive diagnosis of endometriosis, this study developed a novel microfluidic platform utilizing a three-dimensional (3D) polydimethylsiloxane scaffold microchip to efficiently capture circulating endometrial cells …

Patient-derived organoids in gynaecological cancers: emerging tools for therapy and disease modelling.

Patient-derived organoids (PDOs) have emerged as physiologically relevant three-dimensional (3D) culture systems that closely mimic the molecular and histological features of the human endometrium and associated malignancies. Owing to their …

Three-Dimensional Organoid-like Co-Culture of Human Endometrial Endothelial and Stromal Cells to Study Endometriosis-Associated Responses.

Three-dimensional (3D) endothelium-stromal co-cultures were established using human endometrial cells from biopsy of healthy women (n = 13) and serum samples from both healthy and endometriotic women (n = 5). …

Correlations Between Ultrasound Features and Histological Findings in Adenomyosis: A Single-Center Retrospective Study.

Adenomyosis is a benign gynecologic condition characterized by ectopic endometrial glands and stroma present within the myometrium. Background/Objectives: The gold standard in diagnosis is the histology of hysterectomy specimens. Due …

Decidualized posterior compartment deep endometriosis: three-dimensional rendering and Doppler-based vascular assessment.

Inflammasomes meet organoids and artificial intelligence: unraveling the complexity of gynecological inflammation.

Gynecological diseases represent a persistent global health burden. According to a WHO report, the global incidence of gynecological diseases exceeds 65%. Furthermore, over 90% of women suffer from gynecological issues …

Three-Dimensional Architecture of Ectopic Epithelium and Vasculature in Ovarian Endometriosis Revealed by Tissue-Clearing Imaging.

Ovarian endometriosis (OEM) is characterised by ectopic endometrial tissue growth within the ovary. In these ectopic lesions, the ectopic epithelium plays a crucial role in OEM progression and has been …

Engineering the Human Endometrial-Embryo Interface: Breakthroughs in 3D Uterine Models.

Three-dimensional (3D) organoid and co-culture models have emerged as transformative tools for studying human endometrial function, implantation, and placental development, overcoming key limitations of animal and two-dimensional in vitro systems. …