The Colony-Stimulating Factor 3 Receptor (CSF3R), the receptor for granulocyte colony-stimulating factor (G-CSF), has expanded from a hematopoietic regulator to a multifunctional signalling molecule with significant relevance in gynaecological biology. …
Decidualization of endometrial stromal cells involves significant morphological and functional changes in which alpha-smooth muscle actin (αSMA) expression decreases. Meflin, a glycosylphosphatidylinositol-anchored protein, suppresses αSMA expression and inhibits fibrosis in …
Infertility affects one in six individuals worldwide despite the advancement of assisted reproductive technologies. Successful embryo implantation is the first step of pregnancy, which relies on the establishment of a …
Decidualization of human endometrial stromal cells (ESCs) precedes the successful implantation of a human embryo. Improper decidualization has been reported in numerous conditions associated with infertility including endometriosis. Multiple pathways, …
Background: The individual and social burden of endometriosis is high, and the diagnosis is usually delayed by 7-10 years. Menstrual effluent (ME) represents an accessible and uniquely informative biofluid. This …
Endometriosis is a chronic gynecological disorder marked by the growth of endometrial-like tissue outside the uterus, often resulting in pain and infertility and affecting overall quality of life. Despite its …
Endometriosis is a chronic, estrogen-dependent inflammatory disorder that is increasingly recognized as a systemic condition with profound implications for female reproductive potential. In addition to pelvic distortion and impaired folliculogenesis, …
Low vitamin D levels have been associated with female infertility, but the underlying mechanisms are not understood.
Endometriosis is a hormone dependent disease that often accompanies infertility. At present, the incidence rate of endometriosis is on the rise, but its pathogenesis and the mechanism leading to fertility …
Endometriosis is a chronic inflammatory disorder that affects approximately 10% of women of reproductive age and exhibits tumor-like characteristics such as invasion, recurrence, and hormone-dependent proliferation despite its benign nature. …