Latest Articles

Epigenetics, Oxidative Stress, and the Microbiome in Endometriosis: Toward an Integrated Mechanistic Framework for Precision Medicine.

Endometriosis (EM) is a chronic, estrogen-dependent inflammatory disorder affecting approximately 6-10% of women of reproductive age in the general population and remains a major cause of chronic pelvic pain and …

Underpowered study design invalidates conclusions of LTAP versus LWI in peritoneal endometriosis surgery.

Navigating undone science: The search for adequate endometriosis care.

Endometriosis is an estrogen-dependent disease in which tissue similar to the lining of the uterus grows elsewhere in the body leading to a variety of symptoms including heavy and prolonged …

Safety evaluation of a novel progesterone vaginal ring (PVR) for luteal phase support: SARA trial.

After manufacturing changes, the safety and tolerability of the progesterone vaginal ring (PVR) was compared to findings from the similarly designed phase 3 trial. This prospective, open-label, single-arm, multi-center U.S. …

Central sensitization in patients with chronic pelvic pain resistant to hormonal therapy: A cross-sectional study of prevalence and clinical correlates in a tertiary referral cohort.

Chronic pelvic pain (CPP) affects over 25% of women, with endometriosis being a predominant cause. Central sensitization, particularly pelvic and perineal pain central sensitization (PPCS), is increasingly recognized as a …

Postmenopausal bladder endometriosis without exogenous estrogen: a case report and literature review.

Endometriosis is a common estrogen-dependent disorder that typically affects women of reproductive age and generally resolves following menopause. This report describes a rare case of postmenopausal bladder endometriosis (BE) occurring …

Translational Assessment of Omics Approaches in Endometriosis: Bridging Molecular Discovery with Clinical Utility.

Endometriosis affects an estimated 5-10% of women of reproductive age and presents with substantial clinical and biological heterogeneity. Recent clinical guidelines have shifted toward symptom-guided diagnosis supported by expert imaging, …

The Microbiota-Endometriosis Axis: An Immune-Endocrine Integration Model and Emerging Therapeutic Targets.

Endometriosis is a chronic, estrogen-dependent inflammatory disorder characterized by the ectopic implantation and persistence of endometrial-like tissue outside the uterine cavity. Despite its high prevalence and significant impact on quality …

Beyond the pelvis: diagnostic and surgical challenges of thoracic endometriosis syndrome - a retrospective cohort study of 41 patients.

This study provides a comprehensive analysis of surgically managed thoracic endometriosis syndrome (TES) patients, primarily assessing whether diaphragmatic reconstruction is associated with lower postoperative recurrence. Secondarily, the study aims to …

Garcinol Inhibits the Proliferation of Endometriosis Cells by Regulating Cell Cycle Related Genes and Signaling Pathways.

Endometriosis is a common gynecological disease with high recurrence rates after surgery and the lesions keep unlimited proliferative capacity. The effect of garcinol on cell proliferation has not been investigated …