The Colony-Stimulating Factor 3 Receptor (CSF3R), the receptor for granulocyte colony-stimulating factor (G-CSF), has expanded from a hematopoietic regulator to a multifunctional signalling molecule with significant relevance in gynaecological biology. …
Per- and polyfluoroalkyl substances (PFAS) accumulate in reproductive tissues, yet most studies rely on serum measurements. It remains unclear whether serum concentrations adequately reflect levels in target tissues. We evaluated …
Endometrial stromal sarcoma (ESS) is an extremely uncommon uterine malignancy, and commonly arises from preexisting endometriosis. On rare occasions, ESS arises from extrauterine tissues and is known as extra-uterine ESS. …
To explore the material basis and network mechanism of the Guizhi Fuling pills in the treatment of endometriosis and endometrial polyps based on network pharmacology and machine learning. The effective …
Decidualization of endometrial stromal cells involves significant morphological and functional changes in which alpha-smooth muscle actin (αSMA) expression decreases. Meflin, a glycosylphosphatidylinositol-anchored protein, suppresses αSMA expression and inhibits fibrosis in …
Endometriosis is an estrogen-dependent disorder influenced by dysregulated steroidogenesis, oxidative stress, and inflammation. Bisphenol A (BPA), a common endocrine disruptor, has been associated with reproductive dysfunction, but its developmental impacts …
Endometriosis is underpinned by dysfunctional immune responses resulting in failure to clear ectopic endometrial lesions from the peritoneal cavity. The pelvic milieu comprising immature dendritic cells, dysfunctional cytotoxic lymphocytes, and …
Diaphragmatic endometriosis is a rare and often underrecognized manifestation of extrapelvic endometriosis that may lead to severe complications such as diaphragmatic rupture or herniation. We report the case of a …
Endometriosis has been associated with alterations in the reproductive tract microbiota, yet studies focusing on the endometrial microbiome remain inconsistent, partly due to the low-biomass nature of this niche and …
Endometriosis is defined as endometrial tissue outside of the uterus. It is a debilitating, complex, and underdiagnosed condition, impacting approximately 10%-15% of reproductive-aged women worldwide. Endometriosis is associated with chronic …