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Malignant Transformation of Endometriosis: A Rare Case of Extrauterine Endometrial Stromal Sarcoma.

Endometrial stromal sarcoma (ESS) is an extremely uncommon uterine malignancy, and commonly arises from preexisting endometriosis. On rare occasions, ESS arises from extrauterine tissues and is known as extra-uterine ESS. …

Published: April 6, 2026, midnight
Endometrioid Versus Seromucinous Borderline Ovarian Tumors: Divergent Molecular Signatures and a Shared Role as Precursors to Endometrioid Carcinoma.

Endometrioid borderline tumors (EBTs) and seromucinous borderline tumors (SMBTs) are rare ovarian neoplasms with distinct histologic features. However, the molecular profiles of EBTs and SMBTs remain incompletely characterized. We performed …

Published: April 2, 2026, midnight
Dysfunctional white adipose tissue in the progression of endometriosis: The role of the renin-angiotensin system.

Obesity is a multifactorial chronic disease with pandemic-level prevalence, characterized by excessive or abnormal fat accumulation, dysregulation of body homeostasis, and chronic low-grade inflammation. This complex comorbidity shares some etiological …

Published: March 20, 2026, midnight
Physical Activity, Metabolic Dysfunction, and the Kynurenine Pathway in Endometriosis and Polycystic Ovary Syndrome: A Literature Review.

Endometriosis and PCOS are both leading causes of female infertility, each affecting approximately 10% of reproductive-aged women worldwide. Both conditions markedly impair quality of life by affecting physical health, emotional …

Published: March 15, 2026, midnight
Dose-Response And Threshold Effects of a C-reactive Protein-Triglyceride-Glucose Composite Index and Endometriosis Risk: A Cross-Sectional Study.

Endometriosis is a prevalent gynecological disorder associated with chronic low-grade inflammation, yet diagnosis is often delayed because symptoms are non-specific and definitive confirmation typically relies on invasive procedures. Composite indices …

Published: March 10, 2026, midnight
Endometriosis as a Systemic and Complex Disease: Toward Phenotype-Based Classification and Personalized Therapy.

Endometriosis is traditionally conceptualized as a pelvic lesion-centered disease; however, mounting evidence indicates it is a chronic, systemic, and multifactorial inflammatory disorder. This review examines the molecular dialog between ectopic …

Published: Jan. 16, 2026, midnight
Pro-inflammatory cytokines disrupt in vitro preantral follicle development by targeting granulosa and theca cell functions.

Chronic low-grade inflammation is increasingly recognized as a contributing factor to female infertility. Elevated levels of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 are observed in ovarian conditions including …

Published: Jan. 16, 2026, midnight
High-Intensity Focused Ultrasound (HIFU) as a Combined Approach for the Treatment of Recurrent Low-Grade Endometrial Stromal Sarcoma: A Case Report and Literature Review - Frontiers

High-Intensity Focused Ultrasound (HIFU) as a Combined Approach for the Treatment of Recurrent Low-Grade Endometrial Stromal Sarcoma: A Case Report and Literature Review Frontiers

Published: Nov. 10, 2025, 4:21 p.m.
Low-grade endometrial stromal sarcoma arising from extrauterine deep infiltrating endometriosis: a rare, but important differential diagnosis and short review of the literature.

Low-grade endometrial stroma sarcoma is a very rare mesenchymal neoplasm, that is usually found inside the uterine corpus. It is very uncommon that LG-ESS arises from extrauterine foci.

Published: Nov. 5, 2025, midnight
Addressing Meta-Inflammation in the Comprehensive Management of Chronic Pain.

Chronic pain is a widespread condition affecting millions globally, placing significant strain on healthcare systems, as evidenced by the current opioid crisis. Despite advances in pain management, conventional treatments often …

Published: Oct. 18, 2025, midnight
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