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The PKM2/HIF-1α Axis is Involved in the Pathogenesis of Endometriosis via TGF-β1 under Endometrial Polyps.

Endometriosis patients exhibit a cancer-like glycolytic phenotype. The pyruvate kinase M2 (PKM2)/hypoxia-inducible factor-1 alpha (HIF-1α) axis plays important roles in glycolysis-related diseases, but its role in patients with endometrial polyps …

Published: Dec. 31, 2024, midnight
Targeting TET3 in macrophages provides a concept strategy for the treatment of endometriosis.

Endometriosis, characterized by the presence of endometrial-like tissue outside the uterus, is a condition associated with pain and infertility. In this issue of the JCI, Lv et al. illuminate the …

Published: Nov. 1, 2024, midnight
Effects of Shaofu Zhuyu decoction on intestinal flora and fibrosis in a mouse model of endometriosis.

Shaofu Zhuyu decoction has been widely used to treat gynecological diseases; however, its mechanism of action in endometriosis remains unclear. We analyzed Shaofu Zhuyu decoction's chemical composition using ultra-high performance …

Published: Oct. 1, 2024, midnight
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