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From Endometriosis to Lipedema: Toward a Neuroimmune Framework for Pain Amplification in Hormone-Sensitive Disorders.

Background: Endometriosis and lipedema are chronic female-predominant disorders characterized by persistent pain that is frequently disproportionate to anatomical lesion burden. Although traditionally interpreted within distinct lesion-centered frameworks, both conditions exhibit …

Published: July 3, 2026, midnight
Modulating IL-11-dependent matrix stiffness to delay ovarian aging.

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. …

Published: July 2, 2026, midnight
Early-life exposures and risk of multiple gynecological diseases: evidence from a large community-based study of 272,706 women.

Early-life exposures may influence long-term reproductive health, but comprehensive population-based evidence remains limited. This study aimed to evaluate the associations between six early-life factors (long-term/recurrent antibiotic use [LRAU], birth weight, …

Published: July 2, 2026, midnight
Integrating the Central Sensitization Inventory (CSI) into Neuropelveological Practice: A Systematic Review of Endometriosis and Overlapping Pelvic Pain Syndromes.

Background: The surgical management of chronic pelvic pain (CPP), particularly in endometriosis, often focuses on lesion excision or nerve decompression. However, persistent pain frequently occurs despite "anatomical perfection," suggesting central …

Published: July 2, 2026, midnight
Bladder Endometriosis: A Rare Histopathological Entity Diagnosed by Transurethral Resection.

Bladder endometriosis is a rare form of deep infiltrating endometriosis involving the urinary tract, often presenting with nonspecific urinary or pelvic symptoms and mimicking neoplastic conditions. This report describes a …

Published: July 2, 2026, midnight
The evaluation of pharmacotherapy in endometriosis: changes, challenges and difficulties.

Endometriosis presents a multitude of challenges for individuals. Current treatment of the disease is based on pharmacotherapy that aims to relieve pain, improves future fertility, potentially slows disease progression and …

Published: July 1, 2026, midnight
Updated structured report for dynamic ultrasonography in patients with suspected or known endometriosis: Recommendations of the international society for gynecologic endoscopy (ISGE).

To update the 2021 International Society for Gynecologic Endoscopy (ISGE) recommendations for structured reporting of dynamic ultrasound findings in patients with suspected or known endometriosis, integrating recent technical and methodological …

Published: July 1, 2026, midnight
Medically Assisted Reproduction and Hormone-Related Cancers.

It is critical that women undertaking medically assisted reproductive (MAR) treatment and their clinicians know whether the treatments are associated with an increased risk of hormone-related cancers.

Published: July 1, 2026, midnight
Orchestrating the gut microbiota-mitochondrial-immune axis in gynecological diseases: mechanisms and dual-targeting therapeutic strategies.

The "gut microbiota-mitochondria axis" has become the core hub connecting the metabolism, immunity, and endocrine regulation of gynecological diseases. In this review, the hierarchical regulation mechanism of this axis is …

Published: July 1, 2026, midnight
Recurrent Peritoneal Inclusion Cyst With Persistent Pelvic Pain Despite Radiologic Improvement: A Management Challenge.

Peritoneal inclusion cysts (PICs) are benign cystic lesions that most commonly occur in women with a history of prior abdominal surgery, endometriosis, or pelvic inflammatory disease. They arise from the …

Published: July 1, 2026, midnight
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