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Macrophages in endometriosis: key roles and emerging therapeutic opportunities-a narrative review.

Endometriosis is a chronic gynecological disorder affecting approximately 10% of women of reproductive age. It commonly presents with pelvic pain, dysmenorrhea, and infertility, imposing substantial physical, psychological, and social burdens. …

Published: Oct. 21, 2025, midnight
Pro-endometriosis macrophage release of IL-33 is key for endometriosis pain and lesion formation.

Endometriosis is a painful gynecological inflammatory disease affecting up to 10% of females. When released by sensory neurons, calcitonin gene-related peptide (CGRP) shapes immunity, a process known as neuroimmune communication. …

Published: Oct. 21, 2025, midnight
ROBO3 Drives Endometriosis Progression via Dual Wnt/β-Catenin Activation and M2 Macrophage Polarization.

Endometriosis, a prevalent gynecological disorder marked by ectopic growth of endometrial-like tissue, demonstrates malignant tumor-like properties including aggressive adhesion and invasiveness. Emerging evidence implicates roundabout guidance receptor 3 (ROBO3) in …

Published: Oct. 15, 2025, midnight
Endometrial regenerative cell exosome-derived Sirtuin 6 alleviates ulcerative colitis by remodeling macrophage polarization - ScienceDirect.com

Endometrial regenerative cell exosome-derived Sirtuin 6 alleviates ulcerative colitis by remodeling macrophage polarization ScienceDirect.com

Published: Oct. 13, 2025, 8:33 p.m.
Identification and Validation of Iron Metabolism-Related Biomarkers in Endometriosis: A Mendelian Randomization and Single-Cell Transcriptomics Study.

Studies have shown that the iron concentration in the peritoneal fluid of women is associated with the severity of endometriosis. Therefore, investigation of iron metabolism-related genes (IM-RGs) in endometriosis holds …

Published: Oct. 9, 2025, midnight
Extracellular Vesicles Identified as Mediators Between Endometrial Cancer Cells and Tumor-Associated Macrophages - geneonline.com

Extracellular Vesicles Identified as Mediators Between Endometrial Cancer Cells and Tumor-Associated Macrophages geneonline.com

Published: Oct. 7, 2025, 8:36 a.m.
Extracellular Vesicles: Endometrial Cancer and Macrophage Dialogue - Bioengineer.org

Extracellular Vesicles: Endometrial Cancer and Macrophage Dialogue Bioengineer.org

Published: Oct. 7, 2025, 7:27 a.m.
Extracellular Vesicles: Endometrial Cancer and Macrophage Dialogue - BIOENGINEER.ORG

Extracellular Vesicles: Endometrial Cancer and Macrophage Dialogue BIOENGINEER.ORG

Published: Oct. 7, 2025, 7:27 a.m.
TGFB1/SMAD3-Driven Macrophage-Myofibroblast Transition Promotes Fibrosis Progression in Endometriosis.

Endometriosis is a chronic gynecological disorder characterized by progressive fibrosis, which is closely associated with clinical symptoms such as dysmenorrhea and infertility. While myofibroblast activation is central to fibrogenesis, the …

Published: Oct. 7, 2025, midnight
Nanoceria as Next-Generation Immunotherapeutics: Applications in Chronic Inflammation, Cancer, and Tissue Repair.

The immune system is crucial in protecting against disease, but it can also contribute to chronic illnesses when it malfunctions, with different conditions involving either inflammation or immune suppression. Current …

Published: Oct. 4, 2025, midnight
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