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Controversial Roles of Autophagy in Adenomyosis and Its Implications for Fertility Outcomes-A Systematic Review.

Background/Objectives: Adenomyosis is a benign condition where ectopic endometrial glandular tissue is found within the uterine myometrium. Its impact on women's reproductive outcomes is substantial, primarily due to defective decidualization, …

Published: Dec. 10, 2024, midnight
AURKA inhibits the decidualization of the eutopic endometrium in endometriosis through NF-κB p65†.

Endometriosis is an estrogen dependent disease, which is related to infertility. Decidualization is a prerequisite for successful implantation of human embryos, and endometriosis affects the occurrence of decidualization. However, the …

Published: Dec. 3, 2024, midnight
Extracellular vesicle-packaged PKM2 from endometriotic stromal cells promotes endometrial collagen I deposition by inhibiting autophagy in endometriosis.

Aberrant endometrial collagen I deposition during the implantation window impairs endometrial stromal cell (ESC) decidualization, which may contribute to lower pregnancy rate in endometriosis (EMs) patients with in vitro fertilization …

Published: Nov. 23, 2024, midnight
Role of HOXA10 in pathologies of the endometrium.

HOXA10 belongs to the homeobox gene family and is essential for uterine biogenesis, endometrial receptivity, embryo implantation, and stromal cell decidualization. Available evidence suggests that the expression of HOXA10 is …

Published: Nov. 5, 2024, midnight
[The role of leptin in endometrium disorders: literature review].

Leptin is not only the main regulator of energy balance, but also it affects the reproductive and immune systems. Leptin and its receptors are expressed in the endometrium and are …

Published: Nov. 5, 2024, midnight
YAP1 and WWTR1 are required for murine pregnancy initiation.

Endometrial stromal cell decidualization is required for pregnancy success. Although this process is integral to fertility, many of the intricate molecular mechanisms contributing to decidualization remain undefined. One pathway that …

Published: Nov. 1, 2024, midnight
Pregnancy-related decidualization in post-cesarean section scar endometriosis: A case report.

Post-cesarean section decidualized endometriosis is a rare phenomenon where ectopic endometrial cells undergo changes, such as atypia, under the influence of high progesterone levels at the site of cesarean section. …

Published: Sept. 10, 2024, midnight
Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels - Nature.com

Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels Nature.com

Published: June 24, 2024, 7 a.m.
Interleukin-1β induces and accelerates human endometrial stromal cell senescence and impairs decidualization via the c-Jun N-terminal kinase pathway | Cell Death Discovery - Nature.com

Interleukin-1β induces and accelerates human endometrial stromal cell senescence and impairs decidualization via the c-Jun N-terminal kinase pathway | Cell Death Discovery Nature.com

Published: June 15, 2024, 7 a.m.
The involvement of RNA N6-methyladenosine and histone methylation modification in decidualization and endometriosis-associated infertility - Wiley Online Library

The involvement of RNA N6-methyladenosine and histone methylation modification in decidualization and endometriosis-associated infertility Wiley Online Library

Published: Feb. 12, 2024, 8 a.m.
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