Endometriosis (EMS) is a prevalent estrogen-dependent gynecological disorder characterized by ectopic growth of endometrial tissue. Central to its pathophysiology, peritoneal CD14hi macrophages exhibit a pro-EMS phenotype and drive disease progression. …
New therapeutic targets for endometriosis predicted through Mendelian randomization analysis and case-control trials Frontiers
The fibrosis mechanism in endometriosis is not elucidated. We investigated the role of eosinophil in fibrosis of endometriosis. The endometriotic stromal cells (ESCs) and endometrial epithelial cells (EECs) were subjected …
Endometriosis is the presence of endometrial tissue outside the uterine cavity with an accompanying chronic inflammatory process. The etiology of the disease is still not fully understood. An important role …
This study investigated the role of ACSL4 in endometrial receptivity disorders in endometriosis (EMs) and evaluated PRGL493, an ACSL4 inhibitor, as a potential therapeutic target. Bioinformatic analysis identified ACSL4 as …
Endometriosis is a common disease among women of childbearing age. However, the molecular mechanism behind it is still unknown. Therefore, new biomarkers and therapeutic targets are needed to improve the …
The adenosine monophosphate (AMP)-activated protein kinase (AMPK) signalling pathway regulates cell metabolism, inflammation and the immune response. This signalling pathway is essential for maintaining reproductive homeostasis and influencing steroidogenesis, implantation, …
MRGPRX2 served as a therapeutic target for endometriosis‐induced... researchgate.net
The Ras homolog gene family member A (RhoA) is a small GTPase. RhoA plays major roles in cytoskeletal regulation, transcriptional control, and cell cycle maintenance. RhoA is widely expressed in …
Existing evidence shows the importance of circulating cytokines in studying female reproductive system dysfunction. Endometriosis (EM) is thought to be associated with multiple immune cytokines, but its causality has not …