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Interleukin 17A in the fibrotic-related processes in endometrosis in the mare.

Equine endometrosis is a chronic degenerative condition with fibrosis being one of the most significant characteristics. A growing body of evidence indicates the critical role of interleukin (IL)-17 in fibrotic …

Published: Sept. 22, 2025, midnight
Unravelling the Intricate Link: Mast Cells and Estrogen-Induced Pain Sensitization in Endometriosis.

Endometriosis is a prevalent gynaecological disorder characterized by estrogen-dependent lesions. Pain-particularly dysmenorrhea, chronic pelvic pain, and dyspareunia-is the hallmark symptom of endometriosis. While pain mechanisms remain poorly understood, mast cells …

Published: Sept. 21, 2025, midnight
Co-occurrence of endometriosis and uterine fibroids: a systematic review and meta-analysis.

Endometriosis and uterine fibroids are estrogen-dependent gynecological disorders with an increasing burden to women's health worldwide. Despite overlapping symptoms and long-term consequences, the magnitude of their co-occurrence remains unclear.

Published: Sept. 19, 2025, midnight
Decoding uterine (dys)function in fibroids through multimodal assessment of functional determinants: a systematic review and meta-analysis.

Is there a difference in uterine functional determinants between women with fibroids and women without myometrial pathology?

Published: Sept. 18, 2025, midnight
Atypical (Symplastic) Leiomyoma Arising in Pararectal Endometriosis Associated With Metastatic Ovarian Clear Cell Carcinoma: A Case Report.

While very commonly encountered in the uterus, in particular in the wall of the uterine corpus, leiomyomas are far less frequently found in extragenital sites in females. Atypical leiomyomas (synonyms: …

Published: Sept. 8, 2025, midnight
The Impact of Gynecological Pathologies on Patients' Quality of Life from Menarche to Menopause-Literature Review.

Quality of life represents a key area of concern in every stage of life. It is necessary to pay more attention to the factors or conditions that can negatively affect …

Published: Sept. 5, 2025, midnight
Neuroinflammation is responsible for pain in endometriosis - targeting the JAK-STAT pathway and mast cell activation.

Chronic pain is a defining feature of endometriosis and contributes significantly to the diminished quality of life observed in affected individuals. Despite advances in understanding disease pathology, current therapeutic strategies …

Published: Aug. 29, 2025, midnight
Role of Transcription Factor, LIM Homeobox 9 (LHX9) in Inflammatory Response by PGE2 and Thrombin in SERPINA1-Silencing Endometrial Stromal Cells.

Endometriosis is hypothesized to result from retrograde menstruation where cell debris including endometrial stromal cells (ESCs) travel through the fallopian tubes. This chronic inflammatory disease is characterized by inflammatory and …

Published: Aug. 27, 2025, midnight
Spectrum of Histopathologic Findings in Transgender Men Undergoing Gender-Affirming Gynecologic Surgery Following Preoperative Androgen Therapy: A Tertiary Care Center Study.

IntroductionTransgender men are assigned female sex at birth, but identify with a masculine gender identity, prompting them to undergo gender-affirming surgery, usually following androgen therapy, which induces changes in histology …

Published: Aug. 26, 2025, midnight
High-Resolution Spatial Transcriptomics Reveals Fibroblast and Neuroimmune Microenvironments in Endometriosis Lesions.

Endometriosis is a chronic, systemic, inflammatory disease characterized by the presence of endometrium-like tissue growing outside of the uterus. One of its main symptoms is chronic pain and inflammation leading …

Published: Aug. 25, 2025, midnight
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