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Molecular and Immune Microenvironmental Changes Across Endometrial Lesions: A Comprehensive Immunohistochemical and Clinical Analysis of Progression From Benignity to Carcinoma.

Adenomyosis and endometriosis are estrogen-driven disorders with a recognized potential for malignant transformation, particularly through atypical endometriosis. The molecular and immune mechanisms underlying this progression remain incompletely understood. However, clinical …

Published: Dec. 24, 2025, midnight
High-grade uterine endometrial stromal sarcoma harboring GLI1 and MDM2/CDK4 co-amplifications - BioMed Central

High-grade uterine endometrial stromal sarcoma harboring GLI1 and MDM2/CDK4 co-amplifications BioMed Central

Published: Nov. 6, 2025, 2:43 p.m.
Establishment of a Novel In Vitro and In Vivo Model to Understand Molecular Carcinogenesis of Endometriosis-Related Ovarian Neoplasms.

The molecular mechanisms through which endometriosis-related ovarian neoplasms (ERONs) develop from benign endometrioma remain unclear. It is especially a long-standing mystery why ovarian endometrioma has the potential to develop into …

Published: Feb. 25, 2025, midnight
Overexpression of FOS enhances the malignant potential of eutopic endometrial stromal cells in patients with endometriosis‑associated ovarian cancer.

Endometrial cysts of the ovary (EMC) may develop into endometriosis (EM)‑associated ovarian cancer over time (EAOC), but the pathogenesis of this disease has not been determined. In the present study, …

Published: Feb. 21, 2025, midnight
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