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Glycolytic reprogramming and MYH10 K1520 lactylation mediate eutopic endometrial collagen I deposition driven by PKM2-packaged ectopic endometrial extracellular vesicles.

Endometriosis (EMs) is characterized by ectopic lesions that disrupt endometrial decidualization, a process frequently accompanied by aberrant collagen deposition and closely linked to clinical infertility. Extracellular vesicles (EVs) are key …

Published: May 11, 2026, midnight
Prenatal bisphenol A exposure reprograms SF1-lactylation pathways to promote endometriosis susceptibility.

Endometriosis is an estrogen-dependent disorder influenced by dysregulated steroidogenesis, oxidative stress, and inflammation. Bisphenol A (BPA), a common endocrine disruptor, has been associated with reproductive dysfunction, but its developmental impacts …

Published: April 4, 2026, midnight
Histone lactylation modulates ferroptosis in EESCs by regulating... - researchgate.net

Histone lactylation modulates ferroptosis in EESCs by regulating... researchgate.net

Published: June 11, 2025, 3:13 p.m.
Inhibition of histone lactylation promotes ferroptosis in EESCs. A)... - researchgate.net

Inhibition of histone lactylation promotes ferroptosis in EESCs. A)... researchgate.net

Published: June 11, 2025, 3:13 p.m.
Histone lactylation-mediated overexpression of RASD2 promotes endometriosis progression via upregulating the SUMOylation of CTPS1.

Background: Histone lactylation is crucial in a variety of physiopathological processes, however, the function and mechanism of histone lactylation in endometriosis remain poorly understood. Therefore, the objective of this investigation …

Published: Dec. 13, 2024, midnight
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