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Evaluating the efficacy of transcutaneous electrical nerve stimulation in managing chronic pelvic pain in endometriosis patients.

This study sought to assess the impact of transcutaneous electrical nerve stimulation (TENS) prescribed by gynecologists in routine practice on pain, pelvic sensitization, quality of life, and catastrophization scores in …

Published: Feb. 3, 2026, midnight
The Histamine-Associated Inflammatory Landscape of Endometriosis: Molecular Profiling of HDC, HRH1-HRH4, and Cytokines Across Lesion Subtypes.

Pain in endometriosis involves not only nociceptive but also neuropathic and neurogenic components, reflecting its complex nature. Histamine, a biogenic amine, has emerged as a critical mediator connecting inflammation and …

Published: Dec. 24, 2025, midnight
The Impact of Central Sensitization on Patients Perceived Improvement and Quality of Life Following Surgery for Chronic Pelvic Pain: A Pilot Study.

To assess whether higher baseline Central Sensitization Inventory (CSI) scores are linked to quality-of-life outcomes and patient's impression of improvement after surgery for chronic pelvic pain.

Published: Dec. 23, 2025, midnight
Quantitative Sensory Testing in Endometriosis Patients With Cyclic vs. Non-Cyclic Pain-A Case-Control Study.

Endometriosis is a chronic, inflammatory disease with considerable symptom load in affected female patients. Cyclic pain (associated with menstruation) dominates in most patients, but few patients suffer from persistent non-cyclic …

Published: Nov. 7, 2025, midnight
Addressing Meta-Inflammation in the Comprehensive Management of Chronic Pain.

Chronic pain is a widespread condition affecting millions globally, placing significant strain on healthcare systems, as evidenced by the current opioid crisis. Despite advances in pain management, conventional treatments often …

Published: Oct. 18, 2025, midnight
Impact of visceral pain on migraine symptoms in comorbid patients: a retrospective observational study.

Visceral pain and migraine, especially at a high frequency/chronic, are frequent comorbidities, but little is known about their mutual influences. This study investigated if visceral pain-migraine comorbidity involves higher migraine …

Published: Oct. 16, 2025, midnight
Unravelling the Intricate Link: Mast Cells and Estrogen-Induced Pain Sensitization in Endometriosis.

Endometriosis is a prevalent gynaecological disorder characterized by estrogen-dependent lesions. Pain-particularly dysmenorrhea, chronic pelvic pain, and dyspareunia-is the hallmark symptom of endometriosis. While pain mechanisms remain poorly understood, mast cells …

Published: Sept. 21, 2025, midnight
Developing the FIGO-IPPS "R U MOVVING SOMe" classification system for female chronic pelvic pain.

The goal was to develop a pragmatic classification system for conditions associated with chronic pelvic pain (CPP), aiming to enhance diagnosis, management, education, and research of CPP. An international, multidisciplinary …

Published: Sept. 8, 2025, midnight
More than the Lesion: Unraveling the Complexities of Endometriosis-Associated Pain.

Endometriosis is a chronic, estrogen-dependent inflammatory disorder characterized by ectopic endometrium-like tissue, leading to debilitating pain and reduced quality of life. Pain is the hallmark of endometriosis, with individuals experiencing …

Published: Aug. 25, 2025, midnight
Female Dyspareunia and the Relationship to Neurophysiologic Mechanisms: A Scoping Review.

This scoping review aims to evaluate recent studies that examine the relationship between dyspareunia and neurophysiologic factors, and to synthesize their results as it pertains to the development and treatment …

Published: Aug. 20, 2025, midnight
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